Clinical characteristics and long-term outcome in dogs diagnosed with a ductal plate malformation

Ductal plate malformations refer to congenital disorders of the biliary system in the liver. Examples can include von Myenberg complex, congenital hepatic fibrosis, and Caroli’s disease. The purpose of this study is to describe clinical characteristics of dogs diagnosed with this disease over time and long-term outcomes. This study is important because there are no long-term prospective studies in dogs with this disease so prognostic information and clinical course are not known and there are no guidelines for optimal therapy.

After diagnosis, blood work, urine, and other diagnostics will be performed at 6 months and then yearly thereafter and will be covered as part of the study. This is an observational study so treatment is not dictated and is a study evaluating survival and long-term outcomes.


ductal plate malformation

eligibility information

Dogs must have a diagnosis of a ductal plate malformation within the last 3 years to be a part of this study. Specific ductal plate malformations include von Meyenburg complex, congenital hepatic fibrosis, and Caroli malformation.

Exclusion criteria

  • Concurrent copper-associated hepatitis
  • Concurrent interface hepatitis
  • Concurrent morbidity at initial diagnosis/enrollment that would preclude ability to participate in a long-term study (e.g. cancer)

Enrollment Deadline

Enrollment ends May 1, 2034

contact information

Contact Dr. Sarah Shropshire with any questions.