Dr. Stenglein is an Associate Professor in the Microbiology, Immunology, and Pathology department. His laboratory in the Center for Vector-Borne Infectious Diseases studies viruses using a blend of genomic, computational, and traditional laboratory methods. One of the principal goals of the lab is to discover new viruses and to understand if and how they cause disease. We are driven by several motivating factors in this effort: (1) the possibility of improved diagnostics, treatments, and vaccines for infectious diseases of previously unknown etiology, (2) an improved understanding of basic biology, including virus evolution, virus-host interactions, mechanisms of pathogenesis, cellular function, and immune response, (3) a clearer picture of potential zoonotic threats, (4) the opportunity to develop new tools and methods for accomplishing these goals, and (5) the thrill of discovery. Another main goal of the lab is to better understand the viral and host factors and human practices that are driving virus evolution.
PhD, University of Minnesota, 2009BA, Washington University in Saint Louis, 1997
Stenglein MD, Jacobson ER, Chang LW, Sanders C, Hawkins MG, Guzman D, Drazenovich T, Dunker F, Kamaka EK, Fisher D, Reavill DR, Meola LF, Levens G, DeRisi JL (2015) Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections. PLoS Pathogens 11(5):e1004900. Stenglein MD, Jacobson ER, Wozniak EJ, Wellehan JF, Kincaid A, Gordon M, Porter BF, Baumgartner W, Stahl S, Kelley K, Towner JS, DeRisi JL. (2014) Ball Python Nidovirus: a Candidate Etiologic Agent for Severe Respiratory Disease in Python regius. mBio. 5(5). pii: e01484-14.Stenglein MD, Sanders C, Kistler AL, Ruby JG, Franco JY, Reavill DR, Dunker F, DeRisi JL (2012) Identification, characterization, and in vitro culture of highly divergent arenaviruses from boa constrictors and annulated tree boas: a candidate etiological agent for snake inclusion body disease (IBD). mBio 3(4), e00180-12 Stenglein MD, Velazquez E, Greenacre C, Wilkes RP, Ruby JG, Lankton JS, Ganem D, Kennedy MA, DeRisi JL (2012) Complete Genome Sequence of an Astrovirus Identified in a Colony of Domestic Rabbits (Oryctolagus cuniculus) Experiencing an Outbreak of Gastroenteritis. Virology J, 9(1):216.Yozwiak N, Skewes-Cox P, Stenglein MD, Balmaseda A, Harris E, DeRisi J (2012) Virus Identification in Unknown Tropical Febrile Illness Cases Using Deep Sequencing. PLoS Neglected Tropical Diseases. 6(2):e1485