James Terry

The interplay between orthoflavivirus proteins and the host cell is critical during viral infection. Viral proteins operate as multifunctional tools that allow viruses to enter cells, downregulate host defense systems, and facilitate the generation of new infectious virions. My research has focused on assessing orthoflavivirus replication mechanisms and this interplay of viral proteins with host cell systems.

Currently, my research is investigating how the secreted immunomodulating NS1 protein of orthoflavivirus proteins affects astrocytes and their ability to mount an effective defense against infection, as well as how the packaging of NS1 into exosomes changes the outcome of this modulation.