Chris Orton

Helen D. Van Dyke Chair, Interventional Cardiology and Cardiac Surgery, Professor Clinical Sciences

About Chris


PhD, Colorado State University, 1989DVM, Washington State University, 1978MS, Ohio State University, 1982BS, Oregon State University, 1974


Diplomate - American College of Veterinary Surgeons


Arai S, Lacerda CMR, Orton EC. Tissue-gel electrophoresis enhances antigen removal from porcine aortic valve and bovine pericardium. J Heart Valve Dis 19:753-758, 2010.Disatian S, Lacerda C, Orton EC. Tryptophan hydroxylase 1 expression is increased on phenotype-altered canine and human degenerative myxomatous mitral valves. J Heart Valve Dis 19:71-78, 2010.Scruggs SM, Disatian S, Orton EC. Serotonin transporter is down-regulated in late-stage canine degenerative mitral valve disease. J Vet Cardiol 12:163-169, 2010.Arai S, Griffiths LG, Mama K, Hackett TB, Monnet E, Boon J, Carter L, Orton EC. Bioprosthesis valve replacement in dogs with congenital tricuspid valve dysplasia: technique and outcome. J Vet Cardiol, 13:91-99, 2011.Lacerda CMR, Kisiday J, Johnson B, Orton EC. Local serotoinin mediates tensile strain-induced phenotype transformation and matrix alteration in cultured mitral valves. Am J Physiol: Heart & Circ 302:H1983-H1990, 2012.Lacerda CMR, MacLea H, Kisiday J, Orton EC. Static and cyclic tensile strain induce serotonin and myxomatous effector proteins in canine mitral valves. J Vet Cardiol 14:223-230, 2012.Lacerda CMR, Orton EC. Evidence of a role for tensile loading in the pathogenesis of mitral valve degeneration. J Clin Experi Cardiol, 2012. doi:10.4172/2155-9880.S3-004.Orton, EC, Lacerda CMR, MacLea HB. Signaling pathways in mitral valve degeneration. J Vet Cardiol 14:7-17, 2012.Orton, EC. Mitral valve degeneration: Still more questions than answers. J Vet Cardiol 14:3-5, 2012.

Research Specialty

Small Animal Exclusive/Predominant (including pet exotics)