Bradley Borlee

Faculty Microbiology, Immunology, and Pathology

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About Bradley

Dr. Borlee is an Associate Professor of Bacteriology and Boettcher Investigator in the Department of Microbiology, Immunology, and Pathology within the College of Veterinary Medicine and Biomedical Sciences. He was previously a Senior Fellow in the Department of Microbiology at the University of Washington, School of Medicine (Seattle, WA), and earned his Ph.D. conducting microbiology research at the University of Wisconsin (Madison, WI). Highlights of his research career include the pioneering construction of metagenomic libraries to study antibiotic resistance and identification of novel biomolecules from unculturable bacteria. In addition, Dr. Borlee has patented quorum-sensing inhibitors for the development of anti-virulence drug leads. Dr. Borlee’s discovery of a biofilm-induced bacterial adhesin that binds exopolysaccharides and reinforces biofilm structural integrity has been further developed by him into a c-di-GMP biosensor to identify and evaluate antibiofilm therapeutics.

Education

PhD, University of Wisconsin-Madison, 2006BS, University of Wisconsin-Madison, 1998

Publications

Borlee BR, Goldman AD, Murakami K, Samudrala R, Wozniak DJ, and Parsek, MR. Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix. Mol. Microbiol. 2010 Feb;75(4):827-42. (Image chosen for cover, highlighted as one of the most downloaded Mol. Microbiol. papers 2010, and reviewed by the Faculty of 1000)Borlee BR, Geske GD, Blackwell HE and Handelsman J. Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high throughput screening. Appl. Environ. Microbiol. 2010 Dec; 76:8255-8258.Colvin KM, Gordon VD, Murakami K, Borlee BR, Wozniak DJ, Wong GCL, and Parsek MR. The Pel polysaccharide serves multiple functions in the biofilm matrix of Pseudomonas aeruginosa. PLoS Pathog. 2011 Jan 27;7(1):e1001264.

Species Interest

Pseudomonas aeruginosa, Staphylococcus aureus, Burkholderia pseudomallei, Burkholderia mallei, Francisella tularensis, Mycobacterium bovisDr. Borlee maintains three laboratories in the Infectious Disease Research Center at CSU that are focused on the study of biofilm-associated infections.With collaborators at CSU, Dr. Borlee’s research group has developed multiple models to study biofilm-associated infections in animal models of disease to evaluate therapeutic efficacy.

                
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