Christine Olver

Dr. Olver is Professor of Clinical Pathology. Her research interests include: (1) Red blood cell regeneration and reticulocyte maturation: reticulocytes mature into erythrocytes through a series of secretion pathways, including exosomal secretion pathways. Through proteomic and standard biochemical analysis, this work characterizes the molecular mechanism of exosome biogenesis. In the horse, transferrin receptor expression in serum exosomes is upregulated in a model of regenerative anemia. (2) Diagnostic uses of plasma exosomes: Exosomes, subcellular particles secreted by cells into the circulation, provide a snapshot of cellular activity in distant sites, for example in the diagnosis of canine osteosarcoma.