Shane Hentges

Faculty Biomedical Sciences

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            [ProfileText] => Dr. Hentges is Associate Professor of Neurobiology. Her laboratory studies how neurons in the hypothalamus are regulated and how these neurons communicate synaptically with each other as well as other neurons in the larger neural networks that affect energy balance. Current studies are focused on the preopiomelanocortin neurons in the arcuate nucleus of the hypothalamus that play a critical role in maintaining energy balance through the release of the peptide alpha-MSH and thereby affect aspects of food reward through the release of the endogenous opioid beta-endorphin. These neurons also release classical neurotransmitters and endogenous cannabinoids. The primary methods used in the lab are patch clamp electrophysiology in brain slices and primary neuronal cell cultures, retrograde labeling by stereotaxic microinjection, immunofluorescence and confocal imaging in transgenic and knockout mice.
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About Shane

Dr. Hentges is Associate Professor of Neurobiology. Her laboratory studies how neurons in the hypothalamus are regulated and how these neurons communicate synaptically with each other as well as other neurons in the larger neural networks that affect energy balance. Current studies are focused on the preopiomelanocortin neurons in the arcuate nucleus of the hypothalamus that play a critical role in maintaining energy balance through the release of the peptide alpha-MSH and thereby affect aspects of food reward through the release of the endogenous opioid beta-endorphin. These neurons also release classical neurotransmitters and endogenous cannabinoids. The primary methods used in the lab are patch clamp electrophysiology in brain slices and primary neuronal cell cultures, retrograde labeling by stereotaxic microinjection, immunofluorescence and confocal imaging in transgenic and knockout mice.

Education

PhD, Washington State University, 1999BS, Washington State University, 1995

Research Specialty

Small Animal Exclusive/Predominant (including pet exotics)

                
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