Dean Crick

Faculty Microbiology, Immunology, and Pathology

C321 Micro

970-491-3308

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About Dean

Dr. Crick is Professor of Mycobacterial Biochemistry. The research interests of his laboratory involve the metabolism of isoprenoids, one of the most structurally diverse and biologically important families of compounds known in nature. Of particular interest are the M. tuberculosis enzymes involved in the synthesis of isoprenoids (such as prenyl phosphates) and the enzymes that are involved in isoprenoid metabolism, including the glycosyltransferases involved in the cell wall and lipid biosynthesis—keys enzymes in development of anti-mycobacterial drugs as well as drug resistance. An additional research focus is on the enzymes that transport (flip) activated prenyl phosphate-linked saccharides across bacterial membranes in pathogenic organisms.

Education

MS, University of British Columbia, 1984PhD, University of Western Ontario, 1989BS, University of British Columbia, 1982

Publications

Regulation of Polar Peptidoglycan Biosynthesis by Wag31 Phosphorylation in Mycobacteria Charul Jani, Hyungjin Eoh, Jae Jin Lee, Khozima Hamasha, Moodakare Bheema Sahana, Jeong-Sun Han, Seeta Nyayapathy, Jung-Yeon Lee, Joo-Won Suh, Sang Hee Lee, Steve J Rehse, Dean C Crick and Choong-Min Kang BMC Microbiology Accepted for publicationIntraerythrocytic stages of Plasmodium falciparum biosynthesize menaquinone. Tonhosolo R, Gabriel HB, Matsumura MY, Cabral FJ, Yamamoto MM, D'Alexandri FL, Sussmann RA, Belmonte R, Peres VJ, Crick DC, Wunderlich G, Kimura EA, Katzin AM. FEBS Lett. 2010 Dec 1;584(23):4761-8. Epub 2010 Oct 29.PMID: 21036171 Dean C. Crick, Delphi Chatterjee, Michael S. Scherman, and Michael R. McNeil. Structure and Biosynthesis of the Mycobacterial Cell Wall. In Comprehensive Natural Products II Chemistry and Biology; Mander, L., Lui, H.-W., Eds.; Elsevier: Oxford, 2010; volume 6, pp.381–406 .

                
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