Gregory Amberg

Professor, Department of Biomedical Sciences Biomedical Sciences

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            [ProfileText] => Dr. Amberg is Assistant Professor of Cardiovascular Pharmacology.  His laboratory investigates how reactive oxygen species induce pathological changes in arterial smooth muscle associated with hypertension. Results from this research aim to provide insight into understanding why clinical trials with antioxidant supplements generally produce negative results and thereby lead to new pharmacological tools for the clinical prevention and management of hypertension. Blocking the increased calcium channel function should prevent arterial contraction leading to high blood pressure and diseases such as stroke.  Events underlying altered calcium channel function during hypertension are being explored by a combination of total internal reflection fluorescence microscopy, voltage-clamp electrophysiology, fluorescent calcium imaging and video microscopy of intact arteries to seek new therapies for arterial disease.
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About Gregory

Dr. Amberg is Assistant Professor of Cardiovascular Pharmacology. His laboratory investigates how reactive oxygen species induce pathological changes in arterial smooth muscle associated with hypertension. Results from this research aim to provide insight into understanding why clinical trials with antioxidant supplements generally produce negative results and thereby lead to new pharmacological tools for the clinical prevention and management of hypertension. Blocking the increased calcium channel function should prevent arterial contraction leading to high blood pressure and diseases such as stroke. Events underlying altered calcium channel function during hypertension are being explored by a combination of total internal reflection fluorescence microscopy, voltage-clamp electrophysiology, fluorescent calcium imaging and video microscopy of intact arteries to seek new therapies for arterial disease.

Education

PharmD, Idaho State University College of Pharmacy, 1998BS, Idaho State University, 1994PhD, University of Nevada School of Medicine, 2002

Certifications

Clinical
Registered Pharmacist, Nevada State Board of Pharmacy

Species Interest

Ion channelsResearch in the lab involves the study of ion channels in arterial smooth muscle and their impact on arterial function. Changes in ion channel behavior during pathophysiological conditions such as hypertension are of particular interest.Calcium channelsLab projects focus on the investigation of highly localized calcium signals produced by L-type voltage-dependent calcium channels (called "calcium sparklets") located in the plasma membrane of arterial smooth muscle cells. We are investigating redox-dependent modulation of L-type calcium channel function by reactive oxygen species. Experimental approaches used include a combination of patch-clamp electrophysiology, molecular biological methods, pressurized intact arteries and imaging techniques.

                
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