Richard Slayden

Executive Director, Center for Environmental Medicine Microbiology, Immunology, and Pathology

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About Richard

Dr. Slayden is an Professor of Bacteriology and Associate Director for the Center for Environmental Medicine. Dr. Slayden’s laboratory detects and exploits bacterial differentiation into distinct genetically clonal populations optimized for survival, including actively growing, metabolically dormant, hyper-mutable, and altruistically suicidal cells. The Slayden laboratory uses this information in a multi-disciplinary approach to drug discovery and development of preclinical lead compounds with efficacy against targeted bacterial populations, in particular multi-drug resistant M. tuberculosis, F. tularensis, B. pseudomallei and Y. pestis specialized to evading host defenses and drugs. This research allows for targeting of the unique metabolic activities of these bacterial populations.

Education

PhD, Colorado State University, 1997BS, Colorado State University, 1992

Publications

Kunal Kumar, Divya Awasthi, William T. Berger, Peter J. Tonge, Richard A. Slayden, Iwao Ojima. Future Medicinal Chemistry. (2010) 2(8), 1305-1323.Li X, Liu N, Zhang H, Knudson SE, Slayden RA, Tonge PJ. Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6306-9 PMID: 20850304Kumar K, Awasthi D, Lee SY, Zanardi I, Ruzsicska B, Knudson S, Tonge PJ, Slayden RA, Ojima I. Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents. J Med Chem. 2010 Dec 2. [Epub ahead of print]. PMID: 21126020Yan R, Lynn NS, Kingry LC, Slayden RA, Dandy DS, Lear KL. An optical waveguide array biosensor for serology - biomed 2010. Biomed Sci Instrum. 2010;46:45-50.

                
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