Russell Anthony

Hill Professor of Biotechnology, Department of Biomedical Sciences Biomedical Sciences

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            [ProfileText] => The placenta plays critical roles in maintaining and protecting the developing fetus. My research focuses on the establishment of pregnancy, development of the placenta, and placental function in normal and compromised pregnancies.  Our investigations include protein purification sequencing, examination of gene organization and sequence, specific gene transcriptional regulation, microarray assessment of gene expression, mRNA and protein expression, protein-protein interactions, as well as in vivo assessment of altered placental function.  More recently we developed lentiviral-mediated transgenic approaches that alter placental gene expression in vivo (Purcell et al., 2009).  This approach allows the specific targeting of gene expression solely in the placental trophoblast cells, and provides the mechanism to specifically study placental gene function in vivo in a variety of animal models, including the sheep, a very useful model for the in vivo study of placental and fetal physiology.
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About Russell

The placenta plays critical roles in maintaining and protecting the developing fetus. My research focuses on the establishment of pregnancy, development of the placenta, and placental function in normal and compromised pregnancies. Our investigations include protein purification sequencing, examination of gene organization and sequence, specific gene transcriptional regulation, microarray assessment of gene expression, mRNA and protein expression, protein-protein interactions, as well as in vivo assessment of altered placental function. More recently we developed lentiviral-mediated transgenic approaches that alter placental gene expression in vivo (Purcell et al., 2009). This approach allows the specific targeting of gene expression solely in the placental trophoblast cells, and provides the mechanism to specifically study placental gene function in vivo in a variety of animal models, including the sheep, a very useful model for the in vivo study of placental and fetal physiology.

Education

BS, Kansas State University, 1977MS, University of Nebraska, 1979PhD, University of Wyoming, 1983Post-doc, University of Florida, 1985

Publications

Seabrook JL, Cantlon JD, Cooney AJ, McWhorter EE, Fromme BA, Bouma GJ, Anthony RV, Winger QA. 2013. Role of LIN28A in Mouse and Human Trophoblast Cell Differentiation. Biol Reprod accepted.Peel RK, Eckerle GJ, Anthony RV. 2012. Effects of overfeeding naturally-mated adolescent ewes on maternal, fetal, and postnatal lamb growth. J Anim Sci 90:3698-3708. Anthony RV, Cantlon JD, Gates KC, Purcell SH, Clay CM. 2011. Assessing gene function in the ruminant placenta. Soc Reprod Fertil Suppl 67:119-131. Bott, RC, Ashley RL, Henkes LE, Antoniazzi AQ, Bruemmer JE, Niswender GD, Bazer FW, Spencer TE, Smirnova NP, Anthony RV, Hansen TR. 2010. Uterine vein infusion of interferon tau (IFNT) extends luteal lifespan in ewes. Biol Reprod 82:725-735. Purcell SH, Cantlon JD, Wright CD, Henkes LE, Seidel GE, Anthony RV. 2009. The involvement of proline-rich 15 in early conceptus development in sheep. Biol Reprod 81:1112-1121.Jozwik,M, Pietrzycki B, Jozwik M, Anthony RV. 2009. Expression of enzymes regulating placental ammonia homeostasis in human fetal growth restricted pregnancies. Placenta 30:607-612.Wright, CD, Orbus RJ, Regnault TRH, Anthony RV. 2008. Effects of early gestation growth hormone administration on placental and fetal development in sheep. J Endocrinol 198:91-99.Lea RG, Wooding P, Stewart I, Hannah LT, Morton S, Wallace K, Aitken RP, Milne JS, Regnault TR, Anthony RV, Wallace JM. 2007. The expression of ovine placental lactogen, StAR, progesterone associated steroidogenic enzymes in placentae of over-nourished growing adolescent ewes. Reproduction 133: 785-796.Arroyo JA, Anthony RV, Parker TA, Galan HL. 2006. Differential expression of placental and vascular endothelial nitric oxide Synthase (eNOS) in an ovine model of fetal growth restriction. Am J Obstet Gynecol 195:771-777. Erickson Hagen AS, Orbus RJ, Wilkening RB, Regnault TRH, Anthony RV. 2005. Placental expression of angiopoietin-1, angiopoietin-2 and Tie-2 during placental development in an ovine model of placental insufficiency-fetal growth restriction. Ped Res 58:1228-1232. Galan HL, Anthony RV, Rigano S, Parker TA, de Vrijer B, Ferrazzi E, Wilkening RB, Regnault TRH. 2005. Hypertension and abnormal doppler velocimetry in the growth restricted fetus. Am J Obstet Gynecol 192:272-279. Limesand SW, Jeckel KM, Anthony RV. 2004. Pura, a single-stranded DNA binding protein, augments placental lacogen gene transcription. Mol Endocrinol 18:447-457. Regnault TRH, DeVrijer B, Galan HL, Davidsen ML, Trembler KA, Battaglia FC, Wilkening RB, Anthony RV. 2003. The relationship between transplacental O2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction. J Physiol 550:641-656.

                
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