Mark Zabel

Associate Director, Prion Research Center and Associate Dept. Head for Graduate Education Microbiology, Immunology, and Pathology

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About Mark

Dr. Zabel is Professor of Prion Biology and Immunology. Drawing on his background in both immunology and prion biology, Dr. Zabel’s research program focuses on the interaction of prions with cells and receptors of the immune system and lymphoid tissues in the early entry, trafficking, and pathogenesis phases of prion infections. Little is known regarding the cell surface molecules and molecular co-factors that control these events. Using mice engineered to transgenically express both the cervid or ovine normal prion protein gene and selected receptors of the innate immune system, the Zabel lab examines the early lymphoid system distribution of prions and employs vector systems expressing prion-targeted interfering RNA molecules as therapeutic strategies for prion infections.

Education

PhD, University of Utah, 2001MS, Southern Illinois University, 1995BA, Loyola University of Chicago, 1990

Publications

Brady A. Michel, Theodore E. Johnson, Crystal Meyerett, Heather Bender, Breanna Smith, A, Christy Wyckoff, Bruce Pulford, Steven Dow and Mark D. Zabel (2010) Immune Cells Traffic Prions from the Infection Site to Lymph Nodes Within Hours after Intraperitoneal Inoculation. Immunity. Manuscript submitted.Bruce Pulford, Terry Spraker, Christy Wyckoff, Crystal Meyerett, Margaret Wild, Jenny Powers and Mark D. Zabel (2010) Detection of PrPCWD in feces from asymptomatic free-ranging elk by protein misfolding cyclic amplification. Journal of Wildlife Diseases. Manuscript submitted.Bruce Pulford, Natalia Reim, Aimee Bell, Jessica Veatch, Genevieve Forster, Heather Bender, Crystal Meyerett, Scott Hafeman, Brady Michel, Theodore Johnson, A. Christy Wyckoff, Gino Miele, Christian Julius, Jan Kranich, Alan Schenkel, Steven Dow and Mark D. Zabel (2010) Liposome-siRNA-Peptide Complexes Protect and Deliver PrP siRNA to Neuronal Cells and Cure Prion Infection In Vitro. PLoS One. 2010 Jun 14;5(6):e11085.

                
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