Mercedes Gonzalez-Juarrero

Faculty Microbiology, Immunology, and Pathology

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            [ProfileText] => Our interest is to study the basic nature of the cell mediated immune response to mycobacteria infections. Currently our research is focused on the role and dynamics of macrophage and dendritic cell populations during the early and late stages of infection with Mycobacterium tuberculosis. We have recently defined changes in the macrophage cell populations in the lung during the course of pulmonary tuberculosis. Nowadays we are expanding our basic research towards definition of differences in the origin and function of macrophage cell populations derived from mucosal and lymphoid organs. The main aim of this research is to associate particular characteristics from each macrophage cell subset derived from different organs with the development of adaptive immunity, inflammatory responses and susceptibility to mycobacteria infections.
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About Mercedes

Our interest is to study the basic nature of the cell mediated immune response to mycobacteria infections. Currently our research is focused on the role and dynamics of macrophage and dendritic cell populations during the early and late stages of infection with Mycobacterium tuberculosis. We have recently defined changes in the macrophage cell populations in the lung during the course of pulmonary tuberculosis. Nowadays we are expanding our basic research towards definition of differences in the origin and function of macrophage cell populations derived from mucosal and lymphoid organs. The main aim of this research is to associate particular characteristics from each macrophage cell subset derived from different organs with the development of adaptive immunity, inflammatory responses and susceptibility to mycobacteria infections.

Education

B.S., Universidad Complutense de Madrid, Spain, 1982Ph.D., Universidad Autonoma de Madrid, Centro de Biologia Molecular, Spain, 1990

Publications

Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells. Review article González-Juarrero M, O'Sullivan MP. Tuberculosis (Edinb). 2010 Sep 29. [Epub ahead of print] PMID: 20888298 [PubMed - as supplied by publisher] Related citations Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach. Ryan GJ, Hoff DR, Driver ER, Voskuil MI, Gonzalez-Juarrero M, Basaraba RJ, Crick DC, Spencer JS, Lenaerts AJ. PLoS One. 2010 Jun 14;5(6):e11108. PMID: 20559431 [PubMed - indexed for MEDLINE] Local pulmonary immunotherapy with siRNA targeting TGF beta 1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice. Rosas-Taraco, AG,. Higgins, DM, Sánchez-Campillo J, Lee, EJ, Orme IM, González-Juarrero, M in special issue “Inhaled therapies for tuberculosis” in Tuberculosis. In press

                
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