Jeffrey Wilusz

Faculty Microbiology, Immunology, and Pathology

C330 Micro

970-491-0652

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            [ProfileText] => Dr. Wilusz is Professor of RNA Biology and Virology.  Dr. Wilusz’s laboratory channels his unique expertise in RNA stability to decipher the mechanisms of mRNA turnover in mammalian cells.  In 1999 the Wilusz laboratory reported the development of an in vitro assay using HeLa cell cytoplasmic S100 extracts that faithfully reproduces many aspects of regulated deadenylation/turnover of mammalian mRNAs. This system has become the centerpiece of research designed to extensively characterize mRNA decay in human cells, generally regarded as a major determinant of cell-phenotype-specific differentiation and physiology. 
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About Jeffrey

Dr. Wilusz is Professor of RNA Biology and Virology. Dr. Wilusz’s laboratory channels his unique expertise in RNA stability to decipher the mechanisms of mRNA turnover in mammalian cells. In 1999 the Wilusz laboratory reported the development of an in vitro assay using HeLa cell cytoplasmic S100 extracts that faithfully reproduces many aspects of regulated deadenylation/turnover of mammalian mRNAs. This system has become the centerpiece of research designed to extensively characterize mRNA decay in human cells, generally regarded as a major determinant of cell-phenotype-specific differentiation and physiology.

Education

BS, Rutgers University (Cook College), 1981PhD, Duke University, 1985

Publications

Wilusz, C.J. and J Wilusz (2010). Consequences of mRNA Wardrobe Malfunctions. Cell 143: 863-865.Lee, J.E. and J. Wilusz. (2010). Translational Symphony in (hnRNP) C Major for APP. Nature Struct. Mol. Biol. 17:675-676.Wilusz, C.J. and J. Wilusz. (2010) Trans regulation: do mRNAs have a herd mentality? Developmental Cell 18: 333-334. Wilusz, J. (2010) Posttranscriptional – to life scientists, no longer a postscript. Wiley Interdiscip Rev RNA, 1: 1.Sokoloski, K.J., Dickson, A.M., Chaskey, E.L. Garneau, N.L., Wilusz, C.J. and Wilusz, J. (2010). Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells. Cell Host and Microbe, 19:196-207Dickson, A.M. and J. Wilusz. (2010) Polyadenylation: alternative lifestyles of the A-rich (and famous?). EMBO J.29: 1473-1474.Wilusz J. (2010) RNA in the classroom: Beyond the ‘RNA-BC’s” Wiley Interdiscip Rev RNA, 1: 201.Lee, J.E., Lee, J.Y., Wilusz, J., Tian, B and C.J.Wilusz (2010) Systematic analysis of cis elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells. PLOS One, 5: e11201.Brackney, D.E., Scott, J.C., Sagawa, F., Woodward, J.E., Miller, N.A., Shilkey, F.D., Mudge, J., Wilusz, J. Olson, K.E., Blair, C.D., and Ebel, G. D. (2010) C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference Response. PLoS Negl Trop Dis 4(10): e856. doi:10.1371/journal.pntd.0000856.

                
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