Jeffrey Wilusz

Faculty Microbiology, Immunology, and Pathology

C330 Micro

970-491-0652

About Jeffrey

Dr. Wilusz is Professor of RNA Biology and Virology. Dr. Wilusz’s laboratory channels his unique expertise in RNA stability to decipher the mechanisms of mRNA turnover in mammalian cells. In 1999 the Wilusz laboratory reported the development of an in vitro assay using HeLa cell cytoplasmic S100 extracts that faithfully reproduces many aspects of regulated deadenylation/turnover of mammalian mRNAs. This system has become the centerpiece of research designed to extensively characterize mRNA decay in human cells, generally regarded as a major determinant of cell-phenotype-specific differentiation and physiology.

Education

BS, Rutgers University (Cook College), 1981PhD, Duke University, 1985

Publications

Wilusz, C.J. and J Wilusz (2010). Consequences of mRNA Wardrobe Malfunctions. Cell 143: 863-865.Lee, J.E. and J. Wilusz. (2010). Translational Symphony in (hnRNP) C Major for APP. Nature Struct. Mol. Biol. 17:675-676.Wilusz, C.J. and J. Wilusz. (2010) Trans regulation: do mRNAs have a herd mentality? Developmental Cell 18: 333-334. Wilusz, J. (2010) Posttranscriptional – to life scientists, no longer a postscript. Wiley Interdiscip Rev RNA, 1: 1.Sokoloski, K.J., Dickson, A.M., Chaskey, E.L. Garneau, N.L., Wilusz, C.J. and Wilusz, J. (2010). Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells. Cell Host and Microbe, 19:196-207Dickson, A.M. and J. Wilusz. (2010) Polyadenylation: alternative lifestyles of the A-rich (and famous?). EMBO J.29: 1473-1474.Wilusz J. (2010) RNA in the classroom: Beyond the ‘RNA-BC’s” Wiley Interdiscip Rev RNA, 1: 201.Lee, J.E., Lee, J.Y., Wilusz, J., Tian, B and C.J.Wilusz (2010) Systematic analysis of cis elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells. PLOS One, 5: e11201.Brackney, D.E., Scott, J.C., Sagawa, F., Woodward, J.E., Miller, N.A., Shilkey, F.D., Mudge, J., Wilusz, J. Olson, K.E., Blair, C.D., and Ebel, G. D. (2010) C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference Response. PLoS Negl Trop Dis 4(10): e856. doi:10.1371/journal.pntd.0000856.

Links

Pub Med for Jeff WiluszNCBI Bibliography for Jeff WiluszCurrent NIH funding for Wilusz, Jeffrey 

                


stdClass Object
(
    [GetDirectoryInfoByMemberIdResult] => stdClass Object
        (
            [DirectoryInfoResponse] => Array
                (
                    [0] => stdClass Object
                        (
                            [DirectoryDescription] => BS
                            [DirectoryHeader] => Rutgers University (Cook College)
                            [DirectoryNotes] => 
                            [DirectoryType] => Degree
                            [DirectoryYear] => 1981
                        )

                    [1] => stdClass Object
                        (
                            [DirectoryDescription] => PhD
                            [DirectoryHeader] => Duke University
                            [DirectoryNotes] => 
                            [DirectoryType] => Degree
                            [DirectoryYear] => 1985
                        )

                    [2] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Wilusz, C.J. and J Wilusz (2010).  Consequences of mRNA Wardrobe Malfunctions.  Cell 143:  863-865.
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [3] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Lee, J.E. and J. Wilusz.  (2010).  Translational Symphony in (hnRNP) C Major for APP.  Nature Struct. Mol. Biol. 17:675-676.
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [4] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Wilusz, C.J. and J. Wilusz.  (2010) Trans regulation:  do mRNAs have a herd mentality?  Developmental Cell 18: 333-334. 
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [5] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Wilusz, J.  (2010) Posttranscriptional – to life scientists, no longer a postscript.  Wiley Interdiscip Rev RNA, 1: 1.
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [6] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Sokoloski, K.J., Dickson, A.M., Chaskey, E.L. Garneau, N.L., Wilusz, C.J. and Wilusz, J. (2010).  Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells.  Cell Host and Microbe, 19:196-207
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [7] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Dickson, A.M. and J. Wilusz.  (2010) Polyadenylation: alternative lifestyles of the A-rich (and famous?).  EMBO J.29:  1473-1474.
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [8] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Wilusz J. (2010) RNA in the classroom:  Beyond the ‘RNA-BC’s”  Wiley Interdiscip Rev RNA, 1:  201.
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [9] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Lee, J.E., Lee, J.Y., Wilusz, J., Tian, B and C.J.Wilusz (2010)  Systematic analysis of cis elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells.  PLOS One, 5:  e11201.
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [10] => stdClass Object
                        (
                            [DirectoryDescription] => 
                            [DirectoryHeader] => Brackney, D.E., Scott, J.C., Sagawa, F., Woodward, J.E., Miller, N.A., Shilkey, F.D., Mudge, J., Wilusz, J. Olson, K.E., Blair, C.D., and Ebel, G. D. (2010)  C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference Response. PLoS Negl Trop Dis 4(10): e856. doi:10.1371/journal.pntd.0000856.
                            [DirectoryNotes] => 
                            [DirectoryType] => Publication
                            [DirectoryYear] => 
                        )

                    [11] => stdClass Object
                        (
                            [DirectoryDescription] => http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Search&db=pubmed&term=Wilusz%20J
                            [DirectoryHeader] => Pub Med for Jeff Wilusz
                            [DirectoryNotes] => 
                            [DirectoryType] => Link
                            [DirectoryYear] => 
                        )

                    [12] => stdClass Object
                        (
                            [DirectoryDescription] => https://www.ncbi.nlm.nih.gov/sites/myncbi/jeffrey.wilusz.1/bibliography/40755198/public/?sort=date&direction=ascending
                            [DirectoryHeader] => NCBI Bibliography for Jeff Wilusz
                            [DirectoryNotes] => 
                            [DirectoryType] => Link
                            [DirectoryYear] => 
                        )

                    [13] => stdClass Object
                        (
                            [DirectoryDescription] => https://projectreporter.nih.gov/reporter_pisummary.cfm?pi_id=1899520&map=y
                            [DirectoryHeader] => Current NIH funding for Wilusz, Jeffrey
                            [DirectoryNotes] => 
                            [DirectoryType] => Link
                            [DirectoryYear] => 
                        )

                )

        )

)