Dawn Duval

Faculty Clinical Sciences

ACC150 VTH

970-297-4064

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About Dawn

I grew up on a cattle ranch in NE Nevada and began my research career as a Biochemistry undergraduate at the University of Nevada, Reno in the Allie M. Lee Natural Products Lab. My graduate research with Dr. Ruth Billings, a toxicologist in the Pharmacology department at UNR and later Environmental Health Sciences at CSU, explored the ability of cytokines to induce nitric oxide synthase expression in hepatocytes and the potential role this induction plays in liver damage. I expanded my understanding of mechanisms of gene regulation by completing post-doctoral fellowships with Dr. Colin Clay in the Physiology Department (now Biomedical Sciences) at CSU and as a postdoctoral fellow and junior faculty member in the Endocrine Division at the Univ. of Colorado School of Medicine. Current projects explore genetic and gene expression changes contributing to cancer development and metastatic progression in models of hormone refractory breast cancer, canine osteosarcoma and bladder cancer.

Education

PhD, University of Nevada, Reno Cell and Molecular Pharmacology and Physiology Program, 1994BS, University of Nevada, RenoMajor: BiochemistryMinor:Chemistry, Biology, 1989Postdoctoral, Colorado State University: Physiology 1995-1999, 1999Postdoctoral/Junior Faculty, Endocrine Division, University of Colorado Health Sciences 1999-2000, 2000

Publications

Kalet BT, Anglin SR, Handschy A, O’Donoghue LE, Halsey C, Chubb L, Korch C, and Duval DL, Transcription factor Ets1 cooperates with estrogen receptor a to stimulate estradiol-dependent growth in breast cancer cells and tumors, In review at PLOS one, November, 2012.Dailey DD, Anfinsen KP, O’Donoghue LE, Ehrhart EJ, Charles JB, Thamm DH, Powers BE, Jonasdottir TJ, and Duval DL .“HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors, Accepted with revisions at BMC Veterinary Research, Dec. 2012.Andrea Y. Angstadt, Alison Motsinger-Reif, Rachael Thomas, William C. Kisseberthe, C. Guillermo Coutoe, Dawn L. Duval, Dahlia M. Nielsen, Jaime F. Modiano, and Matthew Breen. Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: Signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart. Genes, Chromosomes & Cancer 2011, 50:859–874. Liza E. O’Donoghue, Andrey A. Ptitsyn, Debra A. Kamstock, Janet Siebert, Russell S. Thomas, and Dawn L. Duval. Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome. BMC Cancer. 2010 Sep 22;10(1):506.Sottnik JL, Duval DL, Ehrhart EJ, Thamm DH. An orthotopic, postsurgical model of luciferase transfected murine osteosarcoma with spontaneous metastasis. Clin Exp Metastasis. 2010 Mar;27(3):151-60. Epub 2010 Mar 7.L.E. O’Donoghue, Jason Rivest, and D.L. Duval, PCR-based Species Verification and Microsatellite Analysis for Canine Cell Line Validation. Submitted to J Vet. Diag. Invest. November 2010.A. Jean, A. Gutierrrez-Hartmann, and D.L. Duval. A Pit-1 Threonine 220 Phosphomimic Reduces Binding to Monomeric DNA Sites to Inhibit Ras and Estrogen Stimulation of the Prolactin Gene Promoter. Mol Endocrinol. 2010 Jan;24(1):91-103. Epub 2009 Nov 3.

Species Interest

Classes Taught/Currently teaching:Classes Taught/Currently Teaching:Classes Taught/Currently Teaching:Classes Taught/Currently Teaching:

                
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