Research Topic Directory Cancer Biology

Name E-mail Address Phone Department
970-297-4014Clinical Sciences
970-297-5423Microbiology, Immunology, and Pathology
970-491-6138Microbiology, Immunology, and Pathology
970-491-7579Microbiology, Immunology, and Pathology
970-491-6856College Office
970-297-4034Microbiology, Immunology, and Pathology
970-297-5112Microbiology, Immunology, and Pathology
970-297-5422Microbiology, Immunology, and Pathology

            Array
(
    [0] => stdClass Object
        (
            [AddressPrivacy] => 1
            [BusinessAddress1] => Veterinary Teaching Hospital - 300 W Drake Rd
            [BusinessAddress2] => Animal Cancer Center - ACC 250
            [BusinessCity] => Fort Collins
            [BusinessPostalCode] => 80523
            [BusinessState] => CO
            [CSUId] => 0
            [DepartmentGroup] => 
            [DirectoryPrivacy] => 
            [EName] => sdow
            [EmailAddress] => Steven.Dow@ColoState.EDU
            [EmailPrivacy] => 
            [EmployeeCategory] => Faculty
            [EmployeeTitle] => Professor, Immunology | Director, Center for Immune and Regenerative Medicine
            [EmployeeType] => Faculty
            [FirstName] => Steven
            [GraduationYear] => 
            [HasMemberCV] => 
            [Id] => 1009
            [InternalTitle] => Internal Medicine Clinician
            [LastName] => Dow
            [MemberContacts] => stdClass Object
                (
                )

            [MemberDirectoryProfile] => stdClass Object
                (
                    [Id] => 823
                    [ProfileMetaData] => 
                    [ProfileText] => Dr. Dow received his DVM degree from the University of Georgia and completed a residency in small animal internal medicine at Colorado State University.  He then completed a PhD program in Comparative Pathology in the laboratory of Ed Hoover at Colorado State University.  After that, Dr. Dow completed a post-doctoral fellowship at the National Jewish Center in the laboratory of Dr. Terry Potter, before joining the faculty of the Department of Clinical Sciences at CSU in 2002.  He is currently a professor of immunology in the DCS and the director of the Center for Immune and Regenerative Medicine at CSU.
                )

            [MiddleName] => W
            [NamePrivacy] => 
            [OfficeBldgName] => VTH
            [OfficeRoomName] => ACC250
            [OtherName] => Steven
            [PhonePrivacy] => 1
            [StudentLevel] => 
            [Website] => https://labs.vetmedbiosci.colostate.edu/dow/
        )

    [1] => stdClass Object
        (
            [AddressPrivacy] => 1
            [BusinessAddress1] => Colorado State University
            [BusinessAddress2] => 231 Pathology
            [BusinessCity] => Fort Collins
            [BusinessPostalCode] => 80523
            [BusinessState] => CO
            [CSUId] => 0
            [DepartmentGroup] => 
            [DirectoryPrivacy] => 
            [EName] => pravery
            [EmailAddress] => Paul.Avery@colostate.edu
            [EmailPrivacy] => 
            [EmployeeCategory] => Faculty
            [EmployeeTitle] => Associate Professor
            [EmployeeType] => Faculty
            [FirstName] => Paul
            [GraduationYear] => 
            [HasMemberCV] => 
            [Id] => 2718
            [InternalTitle] => Associate Professor
            [LastName] => Avery
            [MemberContacts] => stdClass Object
                (
                    [MemberContactResponse] => Array
                        (
                            [0] => stdClass Object
                                (
                                    [ContactTypeDescription] => Office
                                    [Id] => 1916
                                    [IsPrimary] => 1
                                    [PhoneNumber] => 970-297-5423
                                )

                            [1] => stdClass Object
                                (
                                    [ContactTypeDescription] => Office
                                    [Id] => 37579
                                    [IsPrimary] => 
                                    [PhoneNumber] => 970-491-6138
                                )

                        )

                )

            [MemberDirectoryProfile] => stdClass Object
                (
                    [Id] => 815
                    [ProfileMetaData] => 
                    [ProfileText] => Dr. Avery is Associate Professor of Clinical Pathology.  His laboratory studies the early immune events surrounding feline immunodeficiency virus (FIV) infection as a means to better understand the critical elements in the control of lentiviral infections, notably HIV.  He specifically studies CD8+ T-lymphocyte and dendritic cell responses to mucosally acquired FIV and the effects that augment the innate and cell-mediated immune response have on host control of the virus.  A second focus is enhanced detection and discrimination of lymphomas and leukemias in dogs and cats.  Immunophenotyping and gene microarray analysis are being used to identify prognostic markers in canine lymphocytic leukemias. 
                )

            [MiddleName] => R
            [NamePrivacy] => 
            [OfficeBldgName] => Diagnostic Medicine Center
            [OfficeRoomName] => 309
            [OtherName] => Paul
            [PhonePrivacy] => 1
            [StudentLevel] => 
            [Website] => 
        )

    [2] => stdClass Object
        (
            [AddressPrivacy] => 
            [BusinessAddress1] => 
            [BusinessAddress2] => 
            [BusinessCity] => 
            [BusinessPostalCode] => 
            [BusinessState] => 
            [CSUId] => 0
            [DepartmentGroup] => 
            [DirectoryPrivacy] => 
            [EName] => aavery
            [EmailAddress] => Anne.Avery@ColoState.EDU
            [EmailPrivacy] => 
            [EmployeeCategory] => Faculty
            [EmployeeTitle] => Associate Professor
            [EmployeeType] => Faculty
            [FirstName] => Anne
            [GraduationYear] => 
            [HasMemberCV] => 
            [Id] => 3106
            [InternalTitle] => Associate Professor
            [LastName] => Avery
            [MemberContacts] => stdClass Object
                (
                    [MemberContactResponse] => stdClass Object
                        (
                            [ContactTypeDescription] => Office
                            [Id] => 2240
                            [IsPrimary] => 1
                            [PhoneNumber] => 970-491-6138
                        )

                )

            [MemberDirectoryProfile] => stdClass Object
                (
                    [Id] => 524
                    [ProfileMetaData] => 
                    [ProfileText] => Dr. Avery is Associate Professor of Immunology and the Director of the Clinical Immunology Laboratory.  The laboratory studies the immunological mechanisms that underlie the development of canine lymphoma and leukemia, and provides diagnostic services to thousands of veterinary clinics and patients each year.  Additional information about research projects and publications from the laboratory can be found at the Clinical Immunology Laboratory website, below. 
                )

            [MiddleName] => C
            [NamePrivacy] => 
            [OfficeBldgName] => Pathology
            [OfficeRoomName] => 231
            [OtherName] => Anne
            [PhonePrivacy] => 
            [StudentLevel] => 
            [Website] => 
        )

    [3] => stdClass Object
        (
            [AddressPrivacy] => 1
            [BusinessAddress1] => 
            [BusinessAddress2] => 
            [BusinessCity] => 
            [BusinessPostalCode] => 
            [BusinessState] => 
            [CSUId] => 0
            [DepartmentGroup] => 
            [DirectoryPrivacy] => 
            [EName] => jrovnak
            [EmailAddress] => Joel.Rovnak@colostate.edu
            [EmailPrivacy] => 
            [EmployeeCategory] => Faculty
            [EmployeeTitle] => Faculty
            [EmployeeType] => Faculty
            [FirstName] => Joel
            [GraduationYear] => 
            [HasMemberCV] => 
            [Id] => 3571
            [InternalTitle] => Faculty
            [LastName] => Rovnak
            [MemberContacts] => stdClass Object
                (
                    [MemberContactResponse] => stdClass Object
                        (
                            [ContactTypeDescription] => Office
                            [Id] => 2683
                            [IsPrimary] => 
                            [PhoneNumber] => 970-491-7579
                        )

                )

            [MemberDirectoryProfile] => stdClass Object
                (
                    [Id] => 86
                    [ProfileMetaData] => 
                    [ProfileText] => The primary intent of my research is the characterization of molecular mechanisms of oncogenesis, particularly where these mechanisms involve viral control of transcription and splicing. Current work is focused on functional analyses of an oncoprotein encoded by walleye dermal sarcoma virus (WDSV), and has lead directly to analyses of protein-protein interactions with cellular transcriptional coactivators in preinitiation complexes. This viral protein is able to differentially regulate host transcription through mechanisms in common with a number of viral oncogenes. Although this research is largely grounded in the current dermal sarcoma model, full investigation of the molecular mechanisms will extend beyond the scope of this virus to include the Tax proteins of bovine and human leukemia viruses, and DNA tumor virus proteins: SV40 Tumor antigens, adenovirus E1A/E1B, and papillomavirus E6/E7.
                )

            [MiddleName] => 
            [NamePrivacy] => 
            [OfficeBldgName] => Pathology
            [OfficeRoomName] => 312
            [OtherName] => Joel
            [PhonePrivacy] => 1
            [StudentLevel] => 
            [Website] => 
        )

    [4] => stdClass Object
        (
            [AddressPrivacy] => 1
            [BusinessAddress1] => 
            [BusinessAddress2] => 
            [BusinessCity] => 
            [BusinessPostalCode] => 
            [BusinessState] => 
            [CSUId] => 0
            [DepartmentGroup] => 
            [DirectoryPrivacy] => 
            [EName] => slquack
            [EmailAddress] => Sandra.Quackenbush@colostate.edu
            [EmailPrivacy] => 
            [EmployeeCategory] => Staff
            [EmployeeTitle] => Associate Dean for Academic and Student Affairs
            [EmployeeType] => Administrative Professional
            [FirstName] => Sandra
            [GraduationYear] => 
            [HasMemberCV] => 
            [Id] => 3950
            [InternalTitle] => Associate Dean for Academic and Student Affairs
            [LastName] => Quackenbush
            [MemberContacts] => stdClass Object
                (
                    [MemberContactResponse] => stdClass Object
                        (
                            [ContactTypeDescription] => Office
                            [Id] => 3022
                            [IsPrimary] => 
                            [PhoneNumber] => 970-491-6856
                        )

                )

            [MemberDirectoryProfile] => stdClass Object
                (
                    [Id] => 616
                    [ProfileMetaData] => 
                    [ProfileText] => Dr. Quackenbush is Professor of Retrovirology.   Her laboratory studies viral-induced oncogenesis, in particular, a newly defined group of retroviruses from fish, which provide a model system of both oncogenesis and tumor regression.  For example, the walleye dermal sarcoma virus (WDSV) is a complex retrovirus encodes three viral accessory/regulatory proteins that are involved in the induction of sarcomas that regress on a seasonal basis.  The biology of these tumors is associated with cyclic differences in the expression of viral transcripts and infectious virus. The Quackenbush lab seeks to determine the mechanisms by which the viral regulatory proteins control transcription, signal transduction, apoptosis, and transformation in the piscine systems. 
                )

            [MiddleName] => L
            [NamePrivacy] => 
            [OfficeBldgName] => Az
            [OfficeRoomName] => W102F
            [OtherName] => Sandra
            [PhonePrivacy] => 1
            [StudentLevel] => 
            [Website] => http://www.cvmbs.colostate.edu/ns/departments/mip/faculty/quackenbush_sandra.aspx
        )

    [5] => stdClass Object
        (
            [AddressPrivacy] => 1
            [BusinessAddress1] => 
            [BusinessAddress2] => 
            [BusinessCity] => 
            [BusinessPostalCode] => 
            [BusinessState] => 
            [CSUId] => 0
            [DepartmentGroup] => 
            [DirectoryPrivacy] => 
            [EName] => danregan
            [EmailAddress] => Daniel.Regan@colostate.edu
            [EmailPrivacy] => 
            [EmployeeCategory] => Faculty
            [EmployeeTitle] => Assistant Professor, Cancer Immunology and Pathology
            [EmployeeType] => Faculty
            [FirstName] => Daniel
            [GraduationYear] => 
            [HasMemberCV] => 
            [Id] => 33234
            [InternalTitle] => Assistant Professor, Cancer Immunology and Pathology
            [LastName] => Regan
            [MemberContacts] => stdClass Object
                (
                    [MemberContactResponse] => stdClass Object
                        (
                            [ContactTypeDescription] => Office
                            [Id] => 36549
                            [IsPrimary] => 
                            [PhoneNumber] => 970-297-4034
                        )

                )

            [MemberDirectoryProfile] => stdClass Object
                (
                    [Id] => 799
                    [ProfileMetaData] => 
                    [ProfileText] => Dr. Regan received his DVM degree from the University of Georgia in 2011, and subsequently completed his residency training in veterinary anatomic pathology (2014) and PhD (Comparative Pathology; 2017) in the Department of Microbiology, Immunology, and Pathology (DMIP) at Colorado State University. In 2018 he accepted his current faculty position in the Flint Animal Cancer Center and DMIP in the College of Veterinary Medicine and Biomedical Sciences at Colorado State University.

Tumors co-evolve in the presence of a complex micro-environment composed of a mixture of resident and recruited host cells. The focus of Dr. Regan’s laboratory is to increase our understanding of the interplay between the immune system and (non-immune) tumor stroma, and how these compartments of the tumor microenvironment promote metastasis as well as respond to and mediate extrinsic mechanisms of resistance to anti-cancer therapy. To investigate this area of cancer biology, his laboratory utilizes a combination of in vitro 3-dimensional tumor co-culture models and animal models, focusing on breast and bone cancer (osteosarcoma). Dr. Regan also has a strong interest in comparative oncology and leveraging naturally occurring cancers in dogs as both a surrogate and intermediary model to evaluate and validate his laboratory’s investigations into the tumor microenvironment. In collaboration with the laboratory of Dr. Steve Dow, we recently targeted an innate immune cell subset known as inflammatory monocytes as an immunotherapy for tumor metastasis, via identification of a small molecule compound that could be re-purposed to effectively inhibit monocyte recruitment. We confirmed the translational potential of these findings by utilizing this drug for monocyte-targeted immunotherapy clinical studies conducted in dogs with spontaneous osteosarcoma. Results from these translational studies have led to a phase I clinical trial in children with osteosarcoma.

Our continued long-term research goal is to fully elucidate the mechanisms by which tumors prime non-malignant host stromal cells of distant organs to promote their metastasis and chemo-resistance, in order to identify novel targets for host-directed stromal therapies which “poison the soil” for effective combination with conventional tumor cell targeted drugs.
                )

            [MiddleName] => Patrick
            [NamePrivacy] => 
            [OfficeBldgName] => Diagnostic Medicine Center
            [OfficeRoomName] => ACC242
            [OtherName] => Dan
            [PhonePrivacy] => 1
            [StudentLevel] => 
            [Website] => 
        )

    [6] => stdClass Object
        (
            [AddressPrivacy] => 1
            [BusinessAddress1] => 
            [BusinessAddress2] => 
            [BusinessCity] => 
            [BusinessPostalCode] => 
            [BusinessState] => 
            [CSUId] => 0
            [DepartmentGroup] => 
            [DirectoryPrivacy] => 
            [EName] => macneill
            [EmailAddress] => Amy.MacNeill@colostate.edu
            [EmailPrivacy] => 
            [EmployeeCategory] => Faculty
            [EmployeeTitle] => Faculty
            [EmployeeType] => Faculty
            [FirstName] => Amy
            [GraduationYear] => 
            [HasMemberCV] => 
            [Id] => 34974
            [InternalTitle] => Faculty
            [LastName] => MacNeill
            [MemberContacts] => stdClass Object
                (
                    [MemberContactResponse] => stdClass Object
                        (
                            [ContactTypeDescription] => Office
                            [Id] => 39487
                            [IsPrimary] => 
                            [PhoneNumber] => 970-297-5112
                        )

                )

            [MemberDirectoryProfile] => stdClass Object
                (
                    [Id] => 694
                    [ProfileMetaData] => 
                    [ProfileText] => Dr. Amy MacNeill graduated from the University of Florida with a B.S. in chemistry in 1994 and a doctorate in veterinary medicine in 1998. Following a year in private practice, she returned to the University of Florida to complete a Ph.D. in the laboratory of Dr. Richard Moyer and a residency in veterinary clinical pathology. She became a board-certified veterinary pathologist in 2004 and was awarded a Ph.D. in virology and immunology in 2005. That same year she joined the faculty at the University of Illinois as an Assistant Professor in the Department of Pathobiology and the Veterinary Diagnostic Laboratory. In 2014, she accepted a clinical pathology faculty position at Colorado State University. She coordinates the Microbiology, Immunology, and Pathology Department Combined Residency Program. Her research interests include isolation and characterization of canine and feline tumor cells and the study of poxviruses as anticancer agents.
                )

            [MiddleName] => Leone
            [NamePrivacy] => 
            [OfficeBldgName] => Diagnostic Medicine Center
            [OfficeRoomName] => 110
            [OtherName] => Amy
            [PhonePrivacy] => 1
            [StudentLevel] => 
            [Website] => 
        )

    [7] => stdClass Object
        (
            [AddressPrivacy] => 1
            [BusinessAddress1] => 
            [BusinessAddress2] => 
            [BusinessCity] => 
            [BusinessPostalCode] => 
            [BusinessState] => 
            [CSUId] => 0
            [DepartmentGroup] => 
            [DirectoryPrivacy] => 
            [EName] => jmunoz
            [EmailAddress] => Juan.Munoz_Gutierrez@colostate.edu
            [EmailPrivacy] => 
            [EmployeeCategory] => Faculty
            [EmployeeTitle] => Faculty
            [EmployeeType] => Faculty
            [FirstName] => Juan
            [GraduationYear] => 
            [HasMemberCV] => 
            [Id] => 38824
            [InternalTitle] => Faculty
            [LastName] => Munoz Gutierrez
            [MemberContacts] => stdClass Object
                (
                    [MemberContactResponse] => stdClass Object
                        (
                            [ContactTypeDescription] => Office
                            [Id] => 43075
                            [IsPrimary] => 
                            [PhoneNumber] => 970-297-5422
                        )

                )

            [MemberDirectoryProfile] => stdClass Object
                (
                    [Id] => 0
                    [ProfileMetaData] => 
                    [ProfileText] => 
                )

            [MiddleName] => Francisco
            [NamePrivacy] => 
            [OfficeBldgName] => Diagnostic Medicine Center
            [OfficeRoomName] => 318
            [OtherName] => Juan
            [PhonePrivacy] => 1
            [StudentLevel] => 
            [Website] => 
        )

)