David Frisbie

Professor Clinical Sciences


(970) 297-4555

About David

After arriving at CSU, Dr. Frisbie began his work on a novel way to treat joint disease using gene therapy, the focus of his Ph.D. Dr. Frisbie is board certified in Large Animal Surgery and is a Diplomate of the ACVS. He joined the faculty as an assistant professor in Equine Surgery in the Dept. of Clinical Sciences in 1999, associate professor (with tenure) in 2007, and professor in 2013. He is a Diplomate of the ACVSMR and a Founding Fellow of ACVS Minimally Invasive Surgery (large animal orthopaedics). Dr. Frisbie has served on the American Association of Equine Practitioners Board of Directors as well as held the position of Secretary on the Board of Directors for the ACSMR. His current areas of research include musculoskeletal diagnosis and treatment. He has evaluated various therapeutics and biologics such as stem cells. As well as looking at novel platforms for diagnosing musculoskeletal disease has developed diagnostic tools such as standing arthroscopy of the equine stifle.


PhD, Molecular biology - gene therapy Colorado State University, 1999MS, Joint Pathobiology Colorado State University, 1996Intern, Cornell University, 1993DVM, University of Wisconsin-Madison, 1992BA, Biochemistry University of Wisconsin, 1987


Diplomate, American College of Sports Medicine and Rehabilitation
Diplomate, American College of Veterinary Surgeons


King MR, Haussler KK, Kawcak CE, McIlwraith CW, Reiser RF 2nd, Frisbie DD, Werpy NM. Biomechanical and histologic evaluation of the effects of underwater treadmill exercise on horses with experimentally induced osteoarthritis of the middle carpal joint. Am J Vet Res 2017;78:558-569. doi: 10.2460/ajvr.78.5.558.Moorman VJ, Frisbie DD, Kawcak CE, McIlwraith CW. Effects of sensor position on kinematic data obtained with an inertial sensor system during gait analysis of trotting horses. J Am Vet Med Assoc 2017;250:548-553. doi: 10.2460/javma.250.5.548.Johnson SA, Frisbie DD. Cartilage therapy and repair in equine athletes. Operative Techniques in Orthopaedics. Oper Tech Orthop 2016;26:155-165. http://dx.doi.org/10.1053/j.oto.2016.06.005.Frisbie DD, McIlwraith CW, Kawcak CE, Werpy NM. Efficacy of intravenous administration of hyaluronan, sodium chondroitin sulfate, and N-acetyl-d-glucosamine for prevention or treatment of osteoarthritis in horses. Am J Vet Res 2016;77:1064-1070. doi: 10.2460/ajvr.77.10.1064.Liebesny PH, Byun S, Hung HH, Pancoast JR, Mroszczyk KA, Young WT, Lee RT, Frisbie DD, Kisiday JD, Grodzinsky AJ. Growth factor-mediated migration of bone marrow progenitor cells for accelerated scaffold recruitment. Tissue Eng Part A 2016;22:917-927. doi: 10.1089/ten.TEA.2015.0524. Ho CP, Surowiec RK, Frisbie DD, Ferro FP, Wilson KJ, Saroki AJ, Fitzcharles EK, Dornan GJ, Philippon MJ. Prospective in vivo comparison of damaged and healthy-appearing articular cartilage specimens in patients with femoroacetabular impingement: comparison of T2 mapping, histologic endpoints, and arthroscopic grading. Arthroscopy 2016;32:1601-1611. doi: 10.1016/j.arthro.2016.01.066.Donnell JR, Frisbie DD, King MR, Goodrich LR, Haussler KK. Comparison of subjective lameness evaluation, force platforms and an inertial-sensor system to identify mild lameness in an equine osteoarthritis model. Vet J 2015;206:136-142. doi: 10.1016/j.tvjl.2015.08.004Frisbie DD. Autologous-conditioned serum: Evidence for use in the knee. J Knee Surg 2015;28:63-66. doi: 10.1055/s-0034-1543956Frisbie DD, McCarthy HE, Archer CW, Barrett MF, McIlwraith CW. Evaluation of articular cartilage progenitor cells for the repair of articular defects in an equine model. J Bone Joint Surg Am 2015;97:484-493. doi: 10.2106/JBJS.N.00404*Donnell JR, Frisbie DD. Use of firocoxib for the treatment of equine osteoarthritis. Veterinary Medicine: Research and Reports 2014;5:159-168. Miller RE, Grodzinsky AJ, Barrett MF, Hung H-H, Frank EH, Werpy NM, McIlwraith CW, Frisbie DD. Effects of the combination of microfracture and self-assembling peptide filling on the repair of a clinically-relevant trochlear defect in an equine model. J Bone Joint Surg 2014;96:1601-1609. doi: 10.2106/JBJS.M.01408Smith R, McIlwraith W, Schweitzer R, Kadler K, Cook J, Caterson B, Dakin S, Heinegård D, Screen H, Stover S, Crevier-Denoix, N, Clegg P, Collins M, Little C, Frisbie D, Kjaer M, van Weeren R, Werpy N, Denoix J-M, Carr A, Goldberg A, Bramlage L, Smith M, Nixon A. Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease. Equine Vet J 2014;46:4-9.Ferris RA, Frisbie DD, McCue PM. Use of mesenchymal stem cells or autologous conditioned serum to modulate the inflammatory response to spermatozoa in mares. Theriogenology 2014;82:36-42. doi: 10.1016/j.theriogenology.2014.02.015 Kopesky PW, Byun S, Vanderploeg EJ, Kisiday JD, Frisbie DD, Grodzinsky AJ. Sustained delivery of bioactive TGF-ß1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells. J Biomed Mater Res A 2014;102:1275-1285. doi: 10.1002/jbm.a.34789*Ferris DJ, Frisbie DD, Kisiday JD, McIlwraith CW, Hague BA, Major MD, Schneider RK, Zubrod CJ, Kawcak CE, Goodrich LR. Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury. Vet Surg 2014;43:255-265. doi: 10.1111/j.1532-950X.2014.12100.x *Frisbie DD, Barrett MF, McIlwraith CW, Ullmer J. Diagnostic stifle joint arthroscopy using a needle arthroscope in standing horses. Vet Surg 2014;43:12-18. doi: 10.1111/j.1532-950X.2013.12068.x

Research Specialty

Equine Exclusive/PredominantSpecial Interests: Equine orthopaedic surgery, joint pathobiology, gene therapy, sports medicine, equine lameness