Research Topic Directory Reproductive Physiology

Name E-mail Address Phone Department
970-491-5388Biomedical Sciences
970-491-8738Biomedical Sciences
970-491-5287Biomedical Sciences
970-491-8934Biomedical Sciences
970-491-7842Biomedical Sciences
970-491-2586Biomedical Sciences
970-491-1769Biomedical Sciences
970-491-5768Biomedical Sciences
970-491-5621Biomedical Sciences

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                    [ProfileText] => Dr. Bouma is Associate Professor of Reproductive Biology and a member of the CSU Animal Reproduction and Biotechnology Laboratory and the Cell and Molecular Biology Program. Dr. Bouma’s research focuses on the genetic and molecular factors that underlie fetal and adult cell differentiation and function in reproductive tissues. Current research projects include uncovering the genetic control of mammalian fetal ovarian development, and identifying the role of non-coding RNA molecules (microRNAs) in fetal and adult ovarian development and function. A second interest is the role of cell-secreted vesicles in mediating cell communication in oocyte maturation. Finally, research projects are ongoing studying the role of stem cell factors in ovarian cancer development and progression.
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                    [ProfileText] => Since 1965, I have taught in dozens of courses at Cornell University, Harvard Medical School, and Colorado State University concerning biomedical sciences and animal sciences, mostly specializing in reproductive physiology. However, I technically retired on September 30, 2011, and although I have been rehired on a part-time basis, my teaching is now limited to occasional guest lectures, and my active involvement in research has decreased as well. I no longer take new graduate and postdoctoral students as major advisor. In recent years, my main research focus has been in vitro fertilization and culture of mammalian embryos, including the related areas of oocyte maturation, micromanipulation, and cryopreservation of embryos and oocytes. Most of this research is with cattle and horses. 
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                    [ProfileText] => Dr. Winger is an Assistant Professor of Reproductive Biology.  Dr. Winger’s research investigates gene regulation in embryonic development. This work now involves isolation of germ cells during fetal stages to determine the role of AP-2 ? protein in germ cell development and specification. These studies employ flow cytometry, quantitative real time RT-PCR, ChIP and protein localization techniques. A second area of research involves investigating the regulation of trophoblast stem cell proliferation and differentiation. This project is currently investigating several known pluripotency factors detected by microarray to be differentially expressed during trophoblast stem cell differentiation. 
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                    [ProfileText] => The placenta plays critical roles in maintaining and protecting the developing fetus. My research focuses on the establishment of pregnancy, development of the placenta, and placental function in normal and compromised pregnancies.  Our investigations include protein purification sequencing, examination of gene organization and sequence, specific gene transcriptional regulation, microarray assessment of gene expression, mRNA and protein expression, protein-protein interactions, as well as in vivo assessment of altered placental function.  More recently we developed lentiviral-mediated transgenic approaches that alter placental gene expression in vivo (Purcell et al., 2009).  This approach allows the specific targeting of gene expression solely in the placental trophoblast cells, and provides the mechanism to specifically study placental gene function in vivo in a variety of animal models, including the sheep, a very useful model for the in vivo study of placental and fetal physiology.
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                    [ProfileText] => Dr. Veeramachaneni is a Professor of Reproductive Biology. Research in his laboratory seeks to determine if deteriorating reproductive health in males is really idiopathic, as male infertility often is labeled, or a consequence of exposure to environmental pollutants. Using a variety of laboratory animal models, long-term reproductive sequelae following developmental exposure to ubiquitous pollutants are evaluated. The compounds that have been studied include anti-androgenic pesticides (DDT and its metabolites; vinclozolin), water disinfection byproducts, and plasticizers (phthalates). Notable findings include the impairment of spermiogenesis long after exposure to common chemical contaminants in drinking water and occurrence of carcinoma in situ lesions in the testis following developmental exposures to DDT.

Veeramachaneni's laboratory also provides morphological/andrological services that span a variety of tissue matrices in clinical research paradigms (from a variety of species including domesticated, wild, and laboratory animals as well as humans) to facilitate identification, and in many instances interpretation, of subtle lesions. The value of evaluation of the gametes at an ultrastructural level to assess potential fertility is particularly recognized by equine practitioners nationally and internationally.  
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                    [ProfileText] => Dr. Bowen in Professor of Reproductive Biology and Virology and Director of the Animal Models Core of the Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Disease.  His laboratory works to understand the pathogenesis of West Nile virus infection in domestic animals, birds and reptiles, and to develop and test vaccines to protect against that disease. Other projects include determining vertebrate and mosquito host competency for Japanese encephalitis virus, and elucidating the pathogenesis of infection and evaluating the potential role of bats in transmission of a number of viruses, and understanding the human-animal interface in the transmission of avian influenza viruses.  
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                    [ProfileText] => Dr. Hansen is the Mabel I. and Henry H. Traubert Professor and Director of the Animal Reproduction and Biotechnology Laboratory and the Equine Reproduction Laboratory.  His research focuses on: 1) embryo-maternal signaling with intent to reduce early embryo mortality (i.e., miscarriage); 2) implantation of the embryo and development of the placenta to better understand and manage intrauterine growth restriction of the fetus; and 3) maternal infection with virus during pregnancy to discover how infections during pregnancy may impair the immune system and development of the fetus.
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