Research Topic Directory Toxicology

Name E-mail Address Phone Department
970-297-5122Environmental and Radiological Health Sciences
970-491-5128Environmental and Radiological Health Sciences
970-491-7043Environmental and Radiological Health Sciences
970-491-5698Environmental and Radiological Health Sciences
970-491-2825Environmental and Radiological Health Sciences
970-491-5652Environmental and Radiological Health Sciences
970-491-5410Environmental and Radiological Health Sciences

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                    [ProfileText] => Research projects focus on neuroinflammatory mechanisms in neurodegenerative disorders, particularly disorders of the basal ganglia such as manganism and Parkinson’s disease. Specific areas of interest include inflammatory activation of microglia and astrocytes, astrocyte biology and calcium signaling, mitochondrial dysfunction, and molecular regulation of neuro-inflammatory genes. Approaches emphasize multi-dimensional fluorescence imaging, transgenic models, and molecular approaches to modulate gene expression in neural cells.
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                    [ProfileText] => Dr. Moreno is an Assistant Professor in the Prion Research Center. Dr. Moreno’s research focuses on the mechanisms of misfolding proteins in the brain during neurodegenerative diseases and aging that cause neuronal toxicity.  Ongoing studies include: 1.) understanding the cellular mechanisms that allow neurons and glia to be vulnerable during aging and neurodegenerative misfolding proteins diseases (NPMDs) such as tauopathies and prion diseases, 2.) utilizing stem cell therapies to therapeutically intervene neuronal loss by decreasing the neuroinflammation and replacing the loss neurons in a safe and translatable way. 3.)  Take a multifaceted approach to neurodegenerative treatments by using genetic and/or small molecules to target cellular stress pathways like the unfolded protein response (UPR), redox homeostasis and oxidative stress in combination with cell therapies to rescue neuronal phenotypes of NPMDs and aging.
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