Lucas ArguesoAssociate Professor and Boettcher Investigator Environmental and Radiological Health Sciences
493 Mrblucas.email@example.com 970-491-3681
Dr. Argueso's research interests include: Chromosomal rearrangements and phenotypic consequences of altered genome architecture. Effects of environmental exposure on copy number variation (CNV) and chromosome structure Molecular mechanisms of DNA double-strand break repair. Structural genome variation in natural yeast populations. Genomics of industrial yeast strains and bioethanol fermentation.
EducationPh.D. - Genetics and Development, Cornell University, 2004M.S. - Genetics and Plant Breeding, The University of Sao Paulo, Brazil, 1997B.S. - Argonomic Engineering, The University of Sao Paulo, Brazil, 1995
PublicationsCarvalho-Netto OV, Carazzolle MF, Mofatto LS, Teixeira P, Noronha MF, Calderón L, Mieczkowski PA, Argueso J. L., Pereira G. 2015 Saccharomyces cerevisiae transcriptional reprograming due to bacterial contamination during industrial scale bioethanol production. Microbial Cell Factories 14: 13.Yadav, P., Harcy, V., Argueso, J. L., Dominska, M., Jinks-Robertson, S. Kim, N. 2014 Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence. PLoS Genetics, 10: e1004839. Vasan, S., Deem, A., Ramakrishnan, S., Argueso, J. L., Malkova, A. 2014 Cascades of genetic instability resulting from compromised break-induced replication. PLoS Genetics, 10: e1004119.Covo, S., Puccia, C. M., Argueso, J. L., Gordenin, D. A., Resnick, M. A. 2014 The sister chromatid cohesion pathway suppresses multiple chromosome gain and chromosome amplification. Genetics, 196: 373-384. *This article was featured in Genetics’ February 2014 issue “Highlights Section”.Zhang, H., Zeidler, A. F. B., Song, W., Puccia, C. M., Malc, E., Greenwell, P. W., Mieczkowski, P. A., Petes, T. D., Argueso, J. L. 2013 Gene copy number variation (CNV) in haploid and diploid strains of the yeast Saccharomyces cerevisiae. Genetics 193: 785-801.Nishant, K. T., Wei, W., Mancera, E., Argueso, J. L., Schlattl, A., Delhomme, N., Ma, X., Bustamante, C., Korbel, J. O., Gu, Z., Steinmetz, L. M., Alani, E. 2010 The baker’s yeast diploid genome is remarkably stable in vegetative growth and meiosis. PLoS Genetics, 6: e1001109. Argueso, J. L., Carazzolle, M. F., Mieczkowski, P. A., Duarte, F. M., Netto, O. V. C., Missawa, S. K., Galzerani, F., Costa, G. G. L., Vidal, R. O., Noronha, M. F., Dominska, M., Andrietta, M. G. S., Andrietta, S. R., Cunha, A. F., Gomes, L. H., Tavares, F. C. A., Alcarde, A. R., Dietrich, F. S., McCusker, J. H., Petes, T. D., Pereira, G. A. G. 2009 Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production. Genome Research, 19: 2258-2270. *This article was featured in Genome Research's issue cover. *This article was featured in the Current Topics section of Microbe Magazine (Microbe, 5:45). *This article was included in the list of "Seminal Yeast Literature" compiled by the curators of Saccharomyces Genome Database comprising "landmark papers in yeast biology". http://wiki.yeastgenome.org/index.php/Seminal_Yeast_LiteratureArgueso, J. L., Westmoreland, J., Mieczkowski, P. A., Gawel, M., Petes, T. D., Resnick, M. A. 2008 Double strand breaks associated with repetitive DNA can reshape the genome. Proceedings of National Academy of Sciences of the United States of America, 105: 11845-11850. *This article was featured in PNAS' issue cover and Commentaries section (PNAS, 105: 11593). *This article was featured in Science Magazine Editors' Choice section (Science, 321: 892). *This article was recommended in F1000Prime as exceptional; highest rating.Surtees, J. A., Argueso, J. L., Alani, E. 2004 Mismatch repair proteins: Key regulators of genetic recombination. Cytogenetic and Genome Research 107: 146-159.Argueso, J. L., Wanat, J., Gemici, Z., Alani, E. 2004 Competing crossover pathways act during meiosis in Saccharomyces cerevisiae. Genetics 168: 1805-1816.Yauk, C. L., Argueso, J. L., Auerbach, S. S., Awadalla, P., Davis, S. R., Demarini, D. M., et al. 2013 Harnessing genomics to identify environmental determinants of heritable disease. Mutation Research 752: 6-9.
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