Clinical characteristics and long-term outcome in cats diagnosed with a ductal plate malformation
Background and purpose of the trial
Ductal plate malformations refer to congenital disorders of the biliary system in the liver. Examples can include von Meyenburg complex, small-duct phenotype, congenital hepatic fibrosis, and Caroli’s disease. The purpose of this study is to describe clinical characteristics of cats diagnosed with this disease over time and long-term outcomes. This study is important because there are no long-term prospective studies in cats with this disease so prognostic information and clinical course are not known and there are no guidelines for optimal therapy.
After diagnosis, blood work (CBC, chemistry panel, coagulation, and bile acids), urine, and fecal testing will be performed at six months post-diagnosis and then yearly thereafter and will be covered as part of the study. This is an observational study so treatment is not dictated and the study evaluates survival and long-term outcomes.
condition(s)
eligibility information
Cats must have a diagnosis of a ductal plate malformation to be a part of this study. Specific ductal plate malformations include von Meyenburg complex, small-duct phenotype, congenital hepatic fibrosis, and Caroli malformation.
Enrollment Deadline
Enrollment ends January 31, 2040
contact information
If you have a patient or own a cat that was diagnosed with DPM, please email Dr. Sarah Shropshire to inquire for eligibility.
