Kelly Du Pont

Microbiology, Immunology, and Pathology

About Kelly

Kelly is a fifth year PhD candidate joint between Brian Geiss and Martin McCullagh in the Chemistry Department. Her research is focused on understanding how flaviviruses, like dengue virus, West Nile virus, and Zika virus, replicate at the molecular level. If we understand how these viruses replicate in vitro, in cell culture, and in mosquitoes, then we are able to provide the insight required for drug and anti-viral therapeutic development. To study replication in flaviviruses she utilizes a combination of computational simulations, protein biochemistry, enzymology, and virology.

Education

BS, Biochemistry, James Madison University, 2015

Publications

Du Pont KE, Davidson RB, McCullagh M, Geiss BJ Motif V regulates energy transduction between the flavivirus NS3 ATPase and RNA-binding cleft. J. Biol. Chem. 2020. 295(6): 1551-1564. doi:10.1074/jbc.RA119.011922Du Pont KE, Sexton NR, McCullagh M, Ebel GD, Geiss BJ A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes. J. Virol. 2020. accepted manuscript. doi:10.1128/JVI.01021-20

                

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