Anne Lenaerts

Faculty Microbiology, Immunology, and Pathology

C312 Micro

970-491-3079

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About Anne

Dr. Lenaerts is a Professor at the Department of Microbiology, Immunology and Pathology, involved in Mycobacterial Therapeutics whose laboratory focuses on development and application of novel preclinical animal models to further both anti-tuberculosis drug discovery and assess anti-mycobacterial resistance and latent tuberculosis. Current research projects explore (1) development of new in vitro assays and animal models to accelerate TB drug evaluation, and (2) analysis of various mycobacterial populations with respect to location, pathology and drug responses through use of selective animal models and advanced pathology methods. Dr. Lenaerts interacts closely with Drs. Lyons, Podell, Basaraba, Ordway and Gonzalez-Juarrero, within the CSU MRL.

Education

PhD, State University of Gent, Belgium, 1996BSc, State University of Gent, Belgium, 1988

Publications

Scott M. Irwin, Brendan Prideaux, Edward R. Lyon, Matthew D. Zimmerman, Elizabeth J. Brooks, Christopher A. Schrupp, Chao Chen, Matthew J. Reichlen, Bryce C. Asay, Martin I. Voskuil, Eric L. Nuermberger, Koen Andries, Michael A. Lyons, Véronique Dartois, Anne J. Lenaerts. 2016. Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice. ACS Infect Dis. 2(4): 251–267. PMCID: PMC4874602I. L. Bartek, M. J. Reichlen, R. W. Honaker, R. L. Leistikow, E. T. Clambey, M. S. Scobey, A. B. Hinds, S. E. Born, C. R. Covey, M. J. Schurr, A. J. Lenaerts, M. I. Voskuil. 2016. Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis. mSphere. 1(4): e00176-16. PMCID: PMC4999920Lenaerts A, Barry CE 3rd, Dartois V. 2015. Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses. Immunol Rev. 264(1):288-307. Review. PMID: 25703567Irwin SM, Driver E, Lyon E, Schrupp C, Ryan G, Gonzalez-Juarrero M, Basaraba RJ, Nuermberger EL, Lenaerts AJ. 2015. Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis. Dis Model Mech. 8(6):591-602. PMID: 26035867R. E. Lee, J. G. Hurdle, J. Liu, D. F. Bruhn, T. Matt, M. Scherman, P. Vaddady, Z. Zheng, J. Qi, R. Akbergenov, S. Das, D. B. Madhura, C. Rathi, A. Trivedi, C. Villellas, R.. B. Lee, Rakesh, S. L. Waidyarachchi, D. Sun, M. R. McNeil, J. A. Ainsa, H. Boshoff, M. Gonzalez-Juarrero, B. Meibohm, E. C. Böttger, A. J. Lenaerts. 2014. Spectinamides: A New Class of Semisynthetic Anti-Tuberculosis Agents that Overcome Native Drug Efflux. Nat. Med. 20(2):152-8. PMID: 24464186

                


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