Mary Ann DeGroote

Microbiology, Immunology, and Pathology

About Mary Ann

Diagnosis and treatment of human mycobacterial infections, including molecular detection of mycobacteria and pre-clinical testing of agents for tuberculosis and nontuberlous mycobacteria. Translational research in human and mycobacterial diseases. Mycobacterium tuberculosis and Mycobacterium abscessus (and other nontuberculous mycobacteria) pre-clinical drug development. Clinical expertise in infectious diseases of humans.


MD, University of Iowa, 1988BA, University of Northern Iowa, 1983


Colorado State Board of Medical Examiners
American Board of Internal Medicine
Board Certified
Examination in Infectious Diseases


Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis. Franzblau SG, DeGroote MA, Cho SH, Andries K, Nuermberger E, Orme IM, Mdluli K, Angulo-Barturen I, Dick T, Dartois V, Lenaerts AJ. Tuberculosis (Edinb). 2012 Nov;92(6):453-88. doi: 10.1016/ Epub 2012 Aug 30.Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery. Gonzalez-Juarrero M, Woolhiser LK, Brooks E, DeGroote MA, Lenaerts AJ. Antimicrob Agents Chemother. 2012 Jul;56(7):3957-9. doi: 10.1128/AAC.00464-12. Epub 2012 A physiologically based pharmacokinetic model for capreomycin. Reisfeld B, Metzler CP, Lyons MA, Mayeno AN, Brooks EJ, Degroote MA. Antimicrob Agents Chemother. 2012 Feb;56(2):926-34. doi: 10.1128/AAC.05180-11. Epub 2011 Dec 5.Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis. De Groote MA, Gruppo V, Woolhiser LK, Orme IM, Gilliland JC, Lenaerts AJ. Antimicrob Agents Chemother. 2012 Feb;56(2):731-8. doi: 10.1128/AAC.05701-11. Epub 2011Preclinical testing of new drugs for tuberculosis: current challenges. Lenaerts AJ, Degroote MA, Orme IM. Trends Microbiol. 2008 Feb;16(2):48-54. doi: 10.1016/j.tim.2007.12.002. Epub 2008 Jan 7.Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. Harris JK, De Groote MA, Sagel SD, Zemanick ET, Kapsner R, Penvari C, Kaess H, Deterding RR, Accurso FJ, Pace NR. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20529-33. Epub 2007 Dec 11. PMID:18077362[PubMed - indexed for MEDLINE] Relationships between Mycobacterium isolates from patients with pulmonary mycobacterial infection and potting soils. De Groote MA, Pace NR, Fulton K, Falkinham JO 3rd.