My group is interested in the molecular virology and biochemistry of mosquito-borne Arboviruses. Arboviruses, including flaviviruses and alphaviruses, are the most prevalent mosquito-borne viral pathogens worldwide. For example, approximately 2/3 of the world’s population is at risk for infection by dengue virus, yellow fever virus, West Nile virus, or related flaviviruses. Arbovirus infection can result in disease symptoms ranging from mild flu-like illness to debilitating encephalitis or death. Because arboviral infection is such a large health and socio-economic problem globally, my research has focused on finding ways to reduce human disease caused by these mosquito-borne viruses. We have a number of collaborative basic and translational research projects that involve flaviviruses (dengue, West Nile, and yellow fever) and alphaviruses (Sindbis, Chikungunya).
BS - Biology, University of Kansas, 1997PhD, Saint Louis University School of Medicine, 2002
Steel JJ and Geiss BJ “A Novel System for Visualization of Alphavirus Assembly”, Journal of Virological Methods 2015 Sep 15;222:158-63.Bullard KM, Gullberg RC, Soltani E, Steel JJ, Geiss BJ*, and Keenan SM* Murine Efficacy and Pharmacokinetic Evaluation of the Flaviviral NS5 Capping Enzyme 2-thioxothiazolidin-4-one Inhibitor BG-323 PLoS ONE Jun 15;10(6):e0130083. doi: 10.1371/journal.pone.0130083. eCollection 2015
(* Co-Corresponding/Senior Authors)
Steel JJ, Franz AWE, Sanchez-Vargas I, Olson KE, Geiss BJ (2013) Subgenomic Reporter RNA System for Detection of Alphavirus Infection in Mosquitoes. PLoS ONE 8(12): e84930. doi:10.1371/journal.pone.0084930Minhas FA, Geiss BJ, and Ben-Hur A. PAIRpred: Partner-specific prediction of interacting residues from sequence and structure. Proteins: Structure, Function, and Bioinformatics 2013 Nov 16. doi: 10.1002/prot.24479.Saeedi, BJ and Geiss, BJ. Regulation of flavivirus RNA synthesis and capping. WIREs RNA 2013 Aug 8 Doi: 10.1002/wrna.1191 Geiss BJ and Wilusz J. Ring around the Ro-sie: RNA Mediated Alterations of PNPase Activity.
Cell 2013 March 28; 153(1): 12-14
Stahla-Beek HJ, April DG, Saeedi BJ, Hannah AM, Keenan SM, and Geiss BJ
Identification of a Novel Antiviral Inhibitor of the Flavivirus Guanylyltransferase Enzyme
Journal of Virology 2012 Aug;86(16):8730-8739