Dr. Stuart Tobet is Professor of Neurobiology and Biomedical Engineering. Dr. Tobet’s research program stretches across several organs, including the organization of clusters of neurons in the hypothalamus that act as key regulators of many homeostatic mechanisms (e.g., body temperature regulation) and motivated behaviors (e.g., feeding, drinking, and reproduction), and regulate many sex-dependent functions. Other foci include neural-immune interactions in the intestine and lung. Time-lapse video microscopy is used to observe cell movements in organotypic slices of tissue, while immunohistochemistry identifies key molecular players in tissues after fixation. Another interest in the lab is developing microfluidic devices and biosensors for following molecular changes in organotypic preparations ex vivo. The Tobet laboratory employs techniques spanning in vivo to in vitro, molecular to cellular, and behavioral.
BS, Tulane University, 1978MS, Massachusetts Institute of Technology, 1982PhD, Massachusetts Institute of Technology, 1985
Schwerdtfeger LA, Tobet SA. Sex differences in anatomic plasticity of gut neuronal-mast cell interactions. Physiol Rep. 2021 Oct;9(19):e15066. doi: 10.14814/phy2.15066. PMID: 34605201 Schwerdtfeger LA, Nealon NJ, Ryan EP, Tobet SA. Human colon function ex vivo: Dependence on oxygen and sensitivity to antibiotic. PLoS One. 2019 May 16;14(5):e0217170. doi: 10.1371/journal.pone.0217170. eCollection 2019. PMID: 31095647 Schwerdtfeger LA, Tobet SA. From organotypic culture to body-on-a-chip: A neuroendocrine perspective. J Neuroendocrinol. 2019 Mar;31(3):e12650. doi: 10.1111/jne.12650. Epub 2018 Nov 7. PMID: 30307079 Goldstein JM, Hale T, Foster SL, Tobet SA, Handa RJ. Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures. Neuropsychopharmacology. 2019 Jan;44(1):59-70. doi: 10.1038/s41386-018-0146-1. Epub 2018 Jul 7. PMID: 30030541 McLean IC, Schwerdtfeger LA, Tobet SA, Henry CS. Powering ex vivo tissue models in microfluidic systems. Lab Chip. 2018 May 15;18(10):1399-1410. doi: 10.1039/c8lc00241j. PMID: 29697131 Frahm KA, Handa RJ, Tobet SA. Embryonic Exposure to Dexamethasone Affects Nonneuronal Cells in the Adult Paraventricular Nucleus of the Hypothalamus.
J Endocr Soc. 2017 Dec 28;2(2):140-153. doi: 10.1210/js.2017-00439. eCollection 2018 Feb 1. PMID: 29383333