Dr. Stuart Tobet is Professor of Neurobiology. Dr. Tobet’s research program examines organization of clusters of neurons deep in the preoptic area and hypothalamus centers that act as key relay stations that control many homeostatic mechanisms (e.g. body temperature regulation) and motivated behaviors (e.g., feeding and drinking), and regulate many sex-dependent functions. Time-lapse video microscopy is used to observe cell movements in slices of embryonic brain tissue. Additional projects involving motion of cells in the adult pituitary (gonadotropes) and ovary (follicles and ova) are interests in the lab particularly as related to developing microfluidic devices and biosensors for following molecular changes. The Tobet laboratory employs techniques spanning in vivo to in vitro, molecular to cellular and behavioral.
BS, Tulane University, 1978MS, Massachusetts Institute of Technology, 1982PhD, Massachusetts Institute of Technology, 1985
Bonthuis P.J., Cox K.H., Searcy B.T., Kumar P., Tobet S., and Rissman E.F.: Of mice and rats: key species variations in the sexual differentiation of brain and behavior. Front. Neuroendocrinology, 31:341-358 (2010). PMID: 20457175McClellan, K.M., Stratton, M.S., Tobet, S.A.: Roles for gamma-aminobutyric acid in the development of the paraventricular nucleus of the hypothalamus. J Comp Neurol, 518(14):2710-2728 (2010). PMID: 20506472Wierman, M.E., Kiseljak-Vassiliades, K., and Tobet, S.: Gonadotropin Releasing Hormone (GnRH) Neuron Migration: Initiation, Maintenance and Cessation as Critical Steps to Ensure Normal Reproductive Function. Front. Neuroendocrinology, in press (2010). PMID: 20650288Kercmar, J., Büdefeld, T., Grgurevic, N., Tobet, S.A., and Majdic G: Adolescent social isolation changes social recognition in adult mice. Behav Brain Res, Sep 16. [Epub ahead of print] (2010). PMID: 20849881Kim, K.W., Li, S., Zhao, H., Peng, B., Tobet, S., Elmquist, J.K., Parker, K.L., and Zhao, L.: CNS-specific Ablation of Steroidogenic Factor 1 Results in Impaired Female Reproductive Function. Mol. Endo., 24:1240-1250 (2010). PMID: 20339005Wadas, B.C., Hartshorn, C.A., Aurand, E.R., Palmer, J.S., Roselli, C.E., Noel, M.L., Gore, A.C., Veeramachaneni, D.N.R., and Tobet, S.A.: Prenatal exposure to vinclozolin disrupts selective aspects of the gonadotropin-releasing hormone neuronal system of the rabbit. J. Neuroendo., 22:518-526 (2010). PMID: 20236232