Herbert Schweizer

Associate Microbiology, Immunology, and Pathology

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About Herbert

Dr. Schweizer is Professor of Bacteriology. Bacterial drug efflux pumps have traditionally been regarded as almost insurmountable challenges of antibacterial drug development. Recent research, however, has demonstrated that bacterial efflux systems can also be exploited for drug discovery, in particular in combating antimicrobial resistance—emerging as the major challenge of the coming century. Ongoing in the Schweizer laboratory are biochemical and genetic studies of multi-drug efflux pumps in the resistance of bacteria such as the Select Agent Burkholderia pseudomallei as well as Pseudomonas aeruginosa.

Education

MS, University of Konstanz, Germany, 1980PhD, University of Konstanz, Germany, 1983BS, University of Konstanz, Germany, 1979

Publications

Schweizer, H.P. Mechanisms of antibiotic resistance in Burkholderia pseudomallei: Implications for treatment of melioidosis. Future Microbiol., in press.Kvitko, B.H., C.R. Cox, D. DeShazer, S.L. Johnson, K.J. Voorhees and H.P. Schweizer. 2012. fX216, a P2-like bacteriophage with broad Burkholderia pseudomallei and B. mallei strain infectivity. BMC Microbiol. 12:289.Choi, K.-H. and H.P. Schweizer. 2012. Characterization of molecular mechanisms controlling fabAB transcription in Pseudomonas aeruginosa. PLoS ONE 7:e45646.Kvitko, B.H., A. Goodyear, K.L. Propst, S.W. Dow and H.P. Schweizer. 2012. Burkholderia pseudomallei siderophore synthesis and hemin uptake is dispensable for lethality in a murine melioidosis model. PLoS Negl. Trop. Dis. 6:e1715Schweizer, H.P. 2012. Understanding efflux in Gram-negative bacteria: opportunities for drug discovery. Exp. Opinion Drug Disc. 7:633-642.Goodyear, A., H. Bielefeldt-Ohmann, H.P. Schweizer and S. W. Dow. 2012. Persistent gastric colonization with Burkholderia pseudomallei and dissemination from the gastrointestinal tract of mice. PLoS ONE 7:e37324. Kvitko, B.H., S. Bruckbauer, J. Prucha, I. McMillan, E.J. Breland, S. Lehman, K. Mladinich, K.-H. Choi, R. Karkhoff-Schweizer, H. P. Schweizer. 2012. A simple method for construction of pir+ Enterobacterial hosts for maintenance of R6K replicon plasmids. BMC Research Notes 5:157.Kumar, A. and H.P. Schweizer. 2011. Evidence of MexT-independent overexpression of MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa in presence of metabolic stress. PLoS ONE 6:e26520. Chantratita, N., D.A. Rholl, B. Sim, V. Wuthiekanun, D. Limmathurotsakul, P. Amornchai, A. Thanwisai, H.H. Chua, W.F. Ooi, M.T.G. Holden, N.P. Day, P. Tan, H.P. Schweizer and S.J. Peacock. 2011. Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei. Proc. Natl. Acad. Sci. U.S.A. 108:17165-17170.Rholl, D.A., K. Papp-Wallace, A.P. Tomaras, M.L. Vasil, R.A. Bonomo and H.P. Schweizer. 2011. Molecular investigations of PenA-mediated ß-lactam resistance in Burkholderia pseudomallei. Front. Microbiol. 2:139.

                
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