Edward Hoover

Faculty Microbiology, Immunology, and Pathology

232 Pathology

970-491-7587

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About Edward

Dr. Hoover's laboratory focuses on the pathogenesis and intervention for retrovirus and prion infections--in particular feline leukemia virus (FeLV), the feline and simian immunodeficiency viruses (FIV, SIV), and most recently the prion disease chronic wasting disease (CWD) of deer and elk. These infectious agents cause both important diseases of animals and models for human disease--i.e. leukemia, HIV infection/AIDS, bovine spongiform encephalopathy (mad cow disease, BSE), and Creutzfeld-Jakob disease. Research in the Hoover Lab led to development of the first successful and most widely used FeLV vaccine, now used to immunize cats worldwide against leukemia. Current work focuses on: (1) the mechanisms whereby prions and retroviruses cross the mucous membranes to initiate infection, (2) the mechanisms and cells involved in transmission and shedding of CWD prions; (3) the potential host range of CWD in cervid and non-cervid species; and (4) experimental vaccines for prion infections.

Education

B.S., University of Illinois, 1965D.V.M., University of Illinois, 1968M.S., The Ohio State University, 1969Ph.D., The Ohio State University, 1970

Certifications

Diplomate
American College of Veterinary Pathologists, Anatomic Pathology

Publications

Henderson, DM*, Matteo M*, Haley NJ, Denkers ND, Nalls AV, Mathiason CK, Caughey B, Hoover EA. Rapid antemortem detection of CWD prions in deer saliva by RT-QuIC. J. Virol. Submitted, 2013 *Contributed equally to the work. Mathiason CK, Nalls,AV, Seelig DM, Kraft S, Carnes K, Anderson K, Hayes-Klug J, and Hoover EA. Susceptibility of domestic cats to chronic wasting disease. J Virol. 2013 Feb;87(4):1947-56. doi: 10.1128/JVI.02592-12. Epub 2012 Dec 12.Denkers ND, Hayes-Klug J, Anderson KR, Seelig DM, Haley NJ, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mathiason CK, Hoover EA.. Aerosol transmission of chronic wasting disease in white-tailed deer. J Virol. 2013 Feb;87(3):1890-2. doi: 10.1128/JVI.02852-12. Epub 2012 Nov 21.Haley NJ, Mathiason CK, Carver S, Telling GC, Zabel MD, Hoover EA. Sensitivity of protein misfolding cyclic amplification versus immunohistochemistry in ante-mortem detection of chronic wasting disease. J Gen Virol. 2012 May;93(Pt 5):1141-50. Epub 2012 Jan 25.Perrott MR, Sigurdson CJ, Mason GL, and Hoover EA: Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol. 2013 Feb;94(Pt 2):432-42. doi: 10.1099/vir.0.046110-0. Epub 2012 Oct 24.

                
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