Edward Hoover

Faculty Microbiology, Immunology, and Pathology

232 Pathology

970-491-7587

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About Edward

Since 1982, Dr. Hoover's laboratory focused on the mechanisms of transmission, pathogenesis, and detection of especially feline retroviruses and more recently the transmission of the prion disease chronic wasting disease (CWD) of cervids (deer, elk, moose, reindeer). Prions are important as the cause of fatal neurologic diseases of animals and models and humans disease--i.e. bovine spongiform encephalopathy (mad cow disease, BSE), sheep scrapes, and Creutzfeldt-Jakob disease. Previous research in the Hoover laboratory led to development of the first successful and most widely used feline leukemia virus (FeLV) vaccine now used to immunize cats worldwide against leukemia, and the way in which feline immunodeficiency virus (FIV) infects and causes disease in cats. Current work is focused on CWD, in particular: (1) the mechanisms whereby prions cross the mucous membranes and travel to the lymphoid tissues and then the brain to cause disease, (2) the mechanisms and cells involved in prion shedding transmission among deer, which appears to be much like the transmission of viruses; (3) the barriers to cross-species transmission of CWD to non-cervid species; and (4) experimental approaches to vaccination against this transmissible prion infection.

Education

Ph.D., The Ohio State University, 1970M.S., The Ohio State University, 1969D.V.M., University of Illinois, 1968B.S., University of Illinois, 1965

Certifications

Diplomate
American College of Veterinary Pathologists, Anatomic Pathology

Publications

Henderson, DM*, Matteo M*, Haley NJ, Denkers ND, Nalls AV, Mathiason CK, Caughey B, Hoover EA. Rapid antemortem detection of CWD prions in deer saliva by RT-QuIC. J. Virol. Submitted, 2013 *Contributed equally to the work. Mathiason CK, Nalls,AV, Seelig DM, Kraft S, Carnes K, Anderson K, Hayes-Klug J, and Hoover EA. Susceptibility of domestic cats to chronic wasting disease. J Virol. 2013 Feb;87(4):1947-56. doi: 10.1128/JVI.02592-12. Epub 2012 Dec 12.Denkers ND, Hayes-Klug J, Anderson KR, Seelig DM, Haley NJ, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mathiason CK, Hoover EA.. Aerosol transmission of chronic wasting disease in white-tailed deer. J Virol. 2013 Feb;87(3):1890-2. doi: 10.1128/JVI.02852-12. Epub 2012 Nov 21.Haley NJ, Mathiason CK, Carver S, Telling GC, Zabel MD, Hoover EA. Sensitivity of protein misfolding cyclic amplification versus immunohistochemistry in ante-mortem detection of chronic wasting disease. J Gen Virol. 2012 May;93(Pt 5):1141-50. Epub 2012 Jan 25.Perrott MR, Sigurdson CJ, Mason GL, and Hoover EA: Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol. 2013 Feb;94(Pt 2):432-42. doi: 10.1099/vir.0.046110-0. Epub 2012 Oct 24.

                
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