Torsten Eckstein

                
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                    [ProfileText] => Bacterial Genetics, Lipidomics, and Physiology.
There are two primary bacterial pathogens our lab is focusing on: Mycobacterium avium with its five distinct subspecies: subsp. avium, subsp. hominissuis, subsp. silvaticum, subsp. lepraemurium, and subsp. paratuberculosis (with its ovine, bovine, and caprine types); and Burkholderia pseudomallei (including the related species B. mallei and B. thailandensis).
The major interest is in defining the Immunolipidome of these pathogens:

To develop diagnostic tests on infectious disease these bacteria are involved in (Johne’s disease in cattle and sheep; Crohn’s disease and ulcerative colitis in humans; and melioidosis in humans);

To identify lipids stimulating innate immunity that could be used as adjuvants and/or immunomodulators;

To determine lipids that could be serve in a vaccine, and

To define new drug target for the treatment of melioidosis.
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                            [DirectoryHeader] => Marta Alonso-Hearn, Torsten M. Eckstein, Sandra Sommer, and Luiz E. Bermudez
A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence
Innate Immunity. 2010;  16(4): p. 235-247
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                            [DirectoryHeader] => Basler T, Holtmann H, Abel J, Eckstein T, Baumer W, Valentin-Weigand P, Goethe R.
Reduced transcript stabilization restricts TNF-alpha expression in RAW264.7 macrophages infected with pathogenic mycobacteria: evidence for an involvement of lipomannan.
J Leukoc Biol. 2010 Jan;87(1):173-83.
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