Diane Ordway

Faculty Microbiology, Immunology, and Pathology

B408 Micro

970-491-7840

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Worldwide the rate of drug-sensitive, multi-drug and extensively drug resistant Mycobacterium tuberculosis cases are increasing. The only available vaccine against M. tuberculosis, M. bovis Bacillus Calmette-Guérin (BCG) is unreliable and the use of anti-mycobacterial drugs has only lead to high rates of drug resistance. Primarily I am interested in elucidating the T cell and macrophage/dendritic cellular immune responses against Mycobacterium tuberculosis through the use of novel multi-parameter flow cytometry in murine and guinea pigs models. These animal models are used to test vaccines and drugs and provide us with information on the nature of induction of protective immunity. 

I also collaborate with scientists in clinical research focused on elucidation of the immune mechanisms against Mycobacterium abscessus, Mycobacterium avium and Mycobacterium paratuberculosis.

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About Diane

Immunology, Vaccines and Drugs against Pathogenic Mycobacteria. Worldwide the rate of drug-sensitive, multi-drug and extensively drug resistant Mycobacterium tuberculosis cases are increasing. The only available vaccine against M. tuberculosis, M. bovis Bacillus Calmette-Guérin (BCG) is unreliable and the use of anti-mycobacterial drugs has only lead to high rates of drug resistance. Primarily I am interested in elucidating the T cell and macrophage/dendritic cellular immune responses against Mycobacterium tuberculosis through the use of novel multi-parameter flow cytometry in murine and guinea pigs models. These animal models are used to test vaccines and drugs and provide us with information on the nature of induction of protective immunity. I also collaborate with scientists in clinical research focused on elucidation of the immune mechanisms against Mycobacterium abscessus, Mycobacterium avium and Mycobacterium paratuberculosis.

Education

PhD, University of London, 2000BSc, Colorado State University, 1992

Publications

Shaobin Shang, Crystal A. Shanley, Megan L. Caraway, Eileen A. Orme, Marcela Henao-Tamayo, Laurel Hascall-Dove, David Ackart, Anne J. Lenaerts, Randall J. Basaraba, Ian M. Orme, and Diane J. Ordway. The activity of TMC 207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs. Antimicrob Agents Chemother. 2010. Oct 11. [Epub ahead of print].Xiyuan Baia, Kathryn Chmura, Alida R. Ovrutsky, Russell P. Bowlerb, Robert Scheinmane Rebecca E. Oberley-Deegan, Haiying Liuf, Shaobin Shang, Diane Ordway, Edward D. Chana, M. tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription. Tuberculosis.2010. in press Edward D. Chan, Xiyuan Bai, Marinka Kartalija, Ian M. Orme, Diane J. Ordway. Host immune response to rapidly-growing mycobacteria, an emerging cause of chronic lung disease. Am J Respir Cell Mol Biol.. 2010 Jan 15. [Epub ahead of print].Marcela I. Henao-Tamayo, Diane J. Ordway, Scott M. Irwin, Crystal Shanley, and Ian M. Orme. Effector memory T lymphocytes predominate in mice chronically infected with Mycobacterium tuberculosis. Clin Vaccine Immunol. 2010. 17:618-25.

                
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