Jifeng Bian

Assistant Professor Microbiology, Immunology, and Pathology

319A Pathology

970-491-5667

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About Jifeng

Dr. Bian received his dental medicine degree at Shandong Medical University, a Ph.D. degree from Shandong University, and his postdoctoral training at University of Kentucky. He joined Dr. Glenn Telling’s laboratory to study prion diseases in 2005. Dr Bian’s work currently focuses: 1. The physiology function of prion protein; 2. The mechanism of prion formation, replication, and evolution; 3. The molecular basis of prion strains; 4. The mechanism of prion interspecies transmission; and the effective treatment for prion diseases by using a combination of biochemical, cellular, transgenic and gene knock-in mouse models.

Education

PhD, Shandong University (Jinan, China), 2003MS, Shandong University (Jinan, China), 1996DMD, Shandong University (Jinan, China), 1993

Publications

Nichols TA, Spraker TR, Rigg TD, Meyerett-Reid C, Hoover C, Michel B, Bian J, Hoover E, Gidlewski T, Balachandran A, O'Rourke K, Telling GC, Bowen R, Zabel MD, VerCauteren KC. Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay. PLoS One. 2013 May 9;8(5): e62455. Bian J, Khaychuk V, Bowling KM, Angers C, Fernandez-Borges N, Visal E, Meyerett-Reid C, Kim S, Calvi C, Bartz J, Hoover EA, Agrimi U, Richt JA, Castilla J, Telling GC. Prion replication without host adaptation during interspecies transmissions. Proc Natl Acad Sci U S A. 2017 Jan 17. pii: 201611891. doi: 10.1073/pnas.1611891114. Davenport KA, Henderson DM, Bian J, Telling GC, Mathiason CK, Hoover EA. Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion. J Virol. 2015 Sep;89(18):9524-31. doi: 10.1128/JVI.01439-15.Bian J, Kang HE, Telling GC. Quinacrine promotes replication and conformational mutation of chronic wasting disease prions. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):6028-33. Highlighted on: Nature 508,291(17 April 2014) doi:10.1038/508291b.Saijo E, Kang HE, Bian J, Bowling KG, Browning S, Kim S, Hunter N, Telling GC. Epigenetic dominance of prion conformers. PLoS Pathog. 2013 Oct;9(10):e1003692. Schoch KM, von Reyn CR, Bian J, Telling GC, Meaney DF, Saatman KE. Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse. J Neurochem. 2013 Jun;125(6):909-20. Nichols TA, Spraker TR, Rigg TD, Meyerett-Reid C, Hoover C, Michel B, Bian J, Hoover E, Gidlewski T, Balachandran A, O'Rourke K, Telling GC, Bowen R, Zabel MD, VerCauteren KC. Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay. PLoS One. 2013 May 9;8(5): e62455. Kang HE, Weng CC, Saijo E, Saylor V, Bian J, Kim S, Ramos L, Angers R, Langenfeld K, Khaychuk V, Calvi C, Bartz J, Hunter N, Telling GC. Characterization of conformation-dependent prion protein epitopes. J Biol Chem. 2012 Oct 26;287(44):37219-32.Mays CE, Yeom J, Kang HE, Bian J, Khaychuk V, Kim Y, Bartz JC, Telling GC, Ryou C. In vitro amplification of misfolded prion protein using lysate of cultured cells. PLoS One. 2011 Mar 28;6(3): e18047.

                
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