About Us

Advancing translational trauma and critical care research

The Veterinary Emergency & Critical Care, Trauma, and Translational Research Laboratory is dedicated to advancing clinically relevant research at the intersection of trauma, resuscitation, and critical care. Based within the Colorado State University Translational Medicine Institute, our laboratory leverages comparative translational models to address high-impact questions in hemorrhagic shock, endothelial dysfunction, pharmacokinetics, and physiologic monitoring.

Our interdisciplinary team develops and validates novel resuscitation strategies, diagnostics, and therapeutic interventions. Through state-of-the-art facilities and robust biospecimen and biobank resources, we conduct rigorous in vivo and ex vivo investigations designed to accelerate translation from bench to bedside—and from veterinary patients to human medicine.

Current and ongoing projects include pharmacokinetic evaluation of resuscitative agents, small-volume and blood-based resuscitation strategies for hemorrhagic shock, endothelial glycocalyx characterization, validation of implantable and field-ready monitoring technologies, and large-scale trauma registry analyses. Collectively, our work aims to improve outcomes for both animal and human patients across the continuum of trauma and critical illness.

Research

Tarbutton JD, Tucker CD, Webb TL, Hall KE. Feasibility and temporal dynamics of endothelial glycocalyx biomarkers in dogs sustaining traumatic injury. J Am Vet Med Assoc. 2025 Dec 29:1-8.

Wedig HM, Talbot CT, Raffe MR, Boller M, Edwards M, Zersen KM, Hall KE. ACVECC Veterinary Committee on Trauma Registry Report 2022-2023. J Vet Emerg Crit Care (San Antonio). 2025 Sep-Oct;35(5):471-479.

Hall KE, Tucker C, Dunn JA, Webb T, Watts SA, Kirkman E, Guillaumin J, Hoareau GL, Pidcoke HF. Breaking barriers in trauma research: A narrative review of opportunities to leverage veterinary trauma for accelerated translation to clinical solutions for pets and people. J Clin Transl Sci. 2024 Apr 5;8(1):e74.

Baird TN, Talbot CT, Hall KE, Hess AM, Zersen KM. Tissue oxygen saturation is positively correlated with oxygen delivery and cardiac output in a canine hemorrhagic shock and resuscitation model. Am J Vet Res. 2024 May 1;85(7):ajvr.23.12.0297.

Cardillo JH, Tarbutton JD, Guillaumin J, Webb TL, Hall KE, Tucker CD, Cavanagh A, Zersen KM. Sidestream dark field imaging and biomarker evaluation reveal minimal significant changes to the microcirculation and glycocalyx in a canine hemorrhagic shock model. Am J Vet Res. 2023 Oct 9;84(12):ajvr.23.06.0134.

Talbot CT, Zersen KM, Hess AM, Hall KE. Shock index is positively correlated with acute blood loss and negatively correlated with cardiac output in a canine hemorrhagic shock model. J Am Vet Med Assoc. 2023 Mar 3;261(6):874-880.

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