Gregory Amberg

Dr. Amberg is Assistant Professor of Cardiovascular Pharmacology. His laboratory investigates how reactive oxygen species induce pathological changes in arterial smooth muscle associated with hypertension. Results from this research aim to provide insight into understanding why clinical trials with antioxidant supplements generally produce negative results and thereby lead to new pharmacological tools for the clinical prevention and management of hypertension. Blocking the increased calcium channel function should prevent arterial contraction leading to high blood pressure and diseases such as stroke. Events underlying altered calcium channel function during hypertension are being explored by a combination of total internal reflection fluorescence microscopy, voltage-clamp electrophysiology, fluorescent calcium imaging and video microscopy of intact arteries to seek new therapies for arterial disease.